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Mr. Smith receiving mitoxantrone (Novantrone) for treatment of secondary progressive multiple sclerosis is closely monitored for a. mood changes and fluid and electrolyte alterations b. leukopenia and cardiac toxicity c. hypoxia d. renal insufficiency Answer: b. leukopenia and cardiac toxicity. Mitoxantrone is an antineoplastic agent used primarily to treat leukemia and lyphoma but is also used to treat secondary progressive MS. Patients need to have laboratory tests ordered and the results clos
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