Tumor Rejection Antigen - an overview | ScienceDirect Topics
Tumors may express antigens that can become targets of antigen-specific T cell responses that lead to tumor rejection. These tumor rejection antigens, which include tumor-specific antigens, cancer-testis antigens, and differentiation antigens, have been exploited for therapeutic purposes including for cancer vaccines, where patients are ...
Identification of tumor rejection antigens and the immunologic ...
2024年8月19日 · Using a custom antigen prediction pipeline, we identified potential tumor rejection antigens with important implications for the development of immunotherapy for medulloblastoma. The current standard of care treatments for medulloblastoma are insufficient as these do not take tumor heterogeneity into account.
Antigen presentation in cancer: insights into tumour ... - Nature
2021年3月9日 · Cancer rejection antigens are the targets of antitumour T cells. Candidates for such rejection antigens include tumour-associated antigens (TAAs; Box 1), viral antigens and...
The Makings of a Tumor Rejection Antigen - Cell Press
1999年9月1日 · The overall implications are that mutated-self, tumor-specific antigens will make effective tumor rejection antigens, whereas shared tumor antigens corresponding to nonmutated tissue-spe cific gene products will make weak tumor rejection antigens.
肿瘤抗原 - 百度百科
肿瘤特异性抗原 （tumor specific antigen,TSA）是 肿瘤细胞 特有的或只存在于某种肿瘤细胞而不存在于 正常细胞 的新抗原。 此类抗原乃通过 肿瘤 在同种系动物间的移植而被证实，故也称为 肿瘤特异性移植抗原 （tumor specific transplantation antigen, TSTA）或肿瘤排斥抗原（tumor rejection antigen, TRA）。 化学或物理因素诱生的肿瘤抗原、自发肿瘤抗原和 病毒诱导 的肿瘤抗原等多属此类。 肿瘤相关抗原 (tumor-associated antigen,TAA)是指非 肿瘤细胞 所特有的、 …
Tumor Rejection Antigen - an overview | ScienceDirect Topics
Clinically successful specific cancer immunotherapy depends on the identification of tumor-rejection antigens (Ags). Historically, tumor Ags have been identified by analyzing either T-cell or antibody responses of cancer patients against the autologous cancer cells.
Tumor Rejection Antigen - an overview | ScienceDirect Topics
The tumor-rejection antigens (TRA) are another family of widely used embryonic markers that are highly expressed in undifferentiated human embryonal carcinoma cells but are almost absent in cells derived from pluripotent embryonal carcinoma (EC) cells, xenograft tumors, and germ cell tumor cell lines [33]. TRA antigens exemplify the rather ...
Using the immune response to attack tumors
Tumor rejection antigens shared between most examples of a tumor, and against which tolerance can be broken, represent candidate antigens for tumor vaccines. The MAGE antigens are candidates because of their limited tissue distribution and their shared expression by …
Targeting Tumor-Rejection Antigens in Melanoma With Tumor …
2021年6月4日 · Immunologists have long searched for tumor-rejection antigens: molecules on tumor cells, but not on normal tissues, that could be recognized by the immune system and would lead the immune system to reject the tumor. The hope was that tumor-rejection antigens would be common to tumor types and shared across patients.
科识-何为肿瘤抗原？ - 知乎专栏
2018年12月5日 · 可以说，肿瘤免疫学理论和实际应用的基础主要取决于肿瘤细胞是否具有肿瘤抗原（tumor antigen）。 目前，肿瘤抗原的分类尚不统一，主要根据肿瘤 抗原的特异性 和肿瘤发生情况的不同，来对其进行分类。