High‐Efficiency, Prevascularization‐Free Macroencapsulation …
2024年9月23日 · The subcutaneous transplantation of small islet masses (≈250 islet equivalent) into diabetic nude mice enable rapid (<1 day) recovery of blood glucose, which remain stable for >120 days. Additionally, antifibrotic drug-loaded multilayer sheets facilitate blood glucose regulation by rat islets at the subcutaneous sites of diabetic ...
Subcutaneous pancreatic islet transplantation without ... - Nature
2023年12月25日 · We harnessed temporary, controlled, inflammation-induced neovascularization to create a modified subcutaneous cavity that supports long-term survival and function of a customized islet ...
Subcutaneous transplantation of human thyroid tissue into a pre ...
2022年1月20日 · Thyroid tissue from human donors was transplanted subcutaneously into the pre-implanted CP device or into the subcutaneous (SC) space alone as a control in a nude Mus musculus model. Transplanted M. musculus were monitored for human serum thyroglobulin (TG) levels for 3 months until the transplants were removed for histological assessment.
Subcutaneous transplantation of human thyroid tissue into a pre ...
2022年1月22日 · Thyroid tissue from human donors was transplanted subcutaneously into the pre-implanted CP device or into the subcutaneous (SC) space alone as a control in a nude Mus musculus model. Transplanted M. musculus were monitored for human serum thyroglobulin (TG) levels for 3 months until the transplants were removed for histological assessment.
Islet transplantation in the subcutaneous space achieves long …
2020年9月7日 · Here we report the successful subcutaneous transplantation of pancreatic islets admixed with a device-free islet viability matrix, resulting in long-term euglycaemia in diverse immune-competent...
Reproducible subcutaneous transplantation of cell sheets into
2011年6月30日 · Here we provide a detailed protocol for handling thin cell sheets, for a simple and highly reproducible subcutaneous transplantation of cell sheets into mice, and for the histological examination...
Subcutaneous clinical islet transplantation in a ... - CellR4
2016年9月30日 · We herein report a first-in-human trial with a newly developed pre-vascularized subcutaneously placed pouch as an innovative approach for human islet implantation. Three longstanding type 1 diabetes subjects underwent subcutaneous implantation of therapeutic and sentinel pouches.
Prevascularization-free Primary Subcutaneous Transplantation of ...
2020年10月23日 · This study investigated whether coencapsulation of hepatocyte growth factor (HGF) with islets in the device enables novel method of prevascularization-free primary subcutaneous transplantation. Methods.
Subcutaneous device-free islet transplantation - PubMed
2023年10月18日 · Subcutaneous islet transplantation is an attractive alternative to islet transplantation because it is simpler, demonstrates lower surgical complication risks, and enables graft monitoring and removal. In this article, we review the current methods of subcutaneous device-free islet transplantation.
Long-term reversal of diabetes by subcutaneous transplantation …
2020年6月21日 · We investigated the therapeutic potential of a combined heparin-esterified collagen-hADSC (HCA)-islet sheet to enhance islet engraftment. This study was designed to assess the efficiency of using EC-Hep as a scaffold for subcutaneous islet transplantation in diabetic athymic mice.