Polyene antimycotics, sometimes referred to as polyene antibiotics, are a class of antimicrobial polyene compounds that target fungi. [1] These polyene antimycotics are typically obtained …

Antifungal agents are also called antimycotic agents. Polyene antifungals bind to ergosterol, the main sterol in the fungal cell membrane, and cause depolarization of the membrane. This …

Polyenes are a group of antifungal drugs with multiple conjugated double bonds and a heavily hydroxylated region on the ring opposite to the conjugated system. These are amphiphilic and …

Aug 14, 2024 · In this review article, we present a thorough analysis of polyene derivatives, their structural modifications, and their influence on their therapeutic effects against various fungal …

This chapter summarizes the more common antifungal agents. Three groups of drugs are emphasized: the polyenes, the azoles, and one antimetabolite. Table 76-1 summarizes the …

Mar 7, 2023 · Antifungal antimicrobials are one drug class that can combat these mycoses. This activity reviews the indications, contraindications, activity, adverse events, and other critical …

Aug 14, 2024 · In this review article, we present a thorough analysis of polyene derivatives, their structural modifications, and their influence on their therapeutic effects against various fungal …

Dec 1, 2020 · Polyenes are the oldest antifungal drugs used for systemic fungal infection treatments. The generally accepted mechanism of action of these natural amphiphilic …

Nov 27, 2020 · Polyenes such as amphotericin B have a controversial image. They are the antifungal drug class with the broadest spectrum, resistance development is still relatively rare …

1. Polyenes First antifungal antibiotics Isolated from Streptomyces spp. General structure: Polyenes (multiple conjugated double bonds) Macrolides (large rings with lactone linkage)