- Antimicrobial polyene compounds that target fungiPolyene antifungals are a class of antimicrobial polyene compounds that target fungi1. They bind to ergosterol, the main sterol in the fungal cell membrane, and cause depolarization of the membrane, leading to cell death23. Polyenes are typically obtained from some species of Streptomyces bacteria1. Amphotericin B, nystatin, and natamycin are the most commonly used polyene antifungals4. They are not absorbed when given orally, so are used to treat fungal infections of the gastrointestinal tract, such as oral thrush2.了解详细信息：✕以上信息汇总借助人工智能技术，若访问原文请查看了解详细信息。
Polyene antimycotics, sometimes referred to as polyene antibiotics, are a class of antimicrobial polyene compounds that target fungi. These polyene antimycotics are typically obtained from some species of...
en.wikipedia.org/wiki/Polyene_antimycoticPolyene antifungals bind to ergosterol, the main sterol in the fungal cell membrane, and cause depolarization of the membrane. This increases the membrane permeability and leads to cell death. They are not absorbed...
www.drugs.com/drug-class/polyenes.htmlIntroduced in the 1950s, the polyenes represent the oldest family of antifungal drugs. 1, 2 Many polyenes have been isolated from Streptomyces spp.; however, only amphotericin B, lipid formulations of amphotericin B...
academic.oup.com/jac/article/66/3/457/729798Polyenes were, after griseofulvin [ 1 ], the first fungal-specific antibiotics on the market and ever since, more than 200 polyene antifungals have been discovered [ 2 ], of which amphotericin B, nystatin and...
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Polyene antimycotics, sometimes referred to as polyene antibiotics, are a class of antimicrobial polyene compounds that target fungi. These polyene antimycotics are typically obtained from certain species of Streptomyces bacteria. Previously, polyenes were thought to bind to ergosterol in the fungal cell membrane, … 展开
Their chemical structures feature a large ring of atoms (in essence, a cyclic ester ring) containing multiple conjugated carbon-carbon double bonds (hence polyene) on … 展开
The natural route to synthesis includes polyketide synthase components. 展开
CC-BY-SA 许可证中的维基百科文本 List of Polyenes - Drugs.com
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Polyene - an overview | ScienceDirect Topics
Polyenes are a group of antifungal drugs with multiple conjugated double bonds and a heavily hydroxylated region on the ring opposite to the conjugated system. These are amphiphilic and …
Polyene-Based Derivatives with Antifungal Activities
2024年8月14日 · In this review article, we present a thorough analysis of polyene derivatives, their structural modifications, and their influence on their therapeutic effects against various fungal strains. Key studies are discussed, illustrating …
Antifungal Agents - Medical Microbiology - NCBI Bookshelf
This chapter summarizes the more common antifungal agents. Three groups of drugs are emphasized: the polyenes, the azoles, and one antimetabolite. Table 76-1 summarizes the …
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Antifungal Antibiotics - StatPearls - NCBI Bookshelf
2023年3月7日 · Antifungal antimicrobials are one drug class that can combat these mycoses. This activity reviews the indications, contraindications, activity, adverse events, and other critical …
Polyene-Based Derivatives with Antifungal Activities - PubMed
2024年8月14日 · In this review article, we present a thorough analysis of polyene derivatives, their structural modifications, and their influence on their therapeutic effects against various fungal …
Polyene - an overview | ScienceDirect Topics
2020年12月1日 · Polyenes are the oldest antifungal drugs used for systemic fungal infection treatments. The generally accepted mechanism of action of these natural amphiphilic …
Amphotericin B and Other Polyenes—Discovery, …
2020年11月27日 · Polyenes such as amphotericin B have a controversial image. They are the antifungal drug class with the broadest spectrum, resistance development is still relatively rare and fungicidal properties are extensive. Yet, …
1. Polyenes First antifungal antibiotics Isolated from Streptomyces spp. General structure: Polyenes (multiple conjugated double bonds) Macrolides (large rings with lactone linkage)
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