Myc - Wikipedia
Myc is a family of regulator genes and proto-oncogenes that code for transcription factors. The Myc family consists of three related human genes: c-myc (MYC), l-myc (MYCL), and n-myc (MYCN). c-myc (also sometimes referred to as MYC) was the first gene to be discovered in this family, due to homology with the viral gene v-myc.
MYC: a multipurpose oncogene with prognostic and therapeutic ...
2021年8月9日 · In this review, MYC regulation and the mechanisms by which MYC adjusts cellular functions and its implication in hematologic malignancies are summarized. Further, we also discuss potential inhibitors of MYC that could be …
The MYC oncogene is a global regulator of the immune response
2018年5月3日 · MYC can regulate PD-L1 and CD47 immune checkpoint expression. MYC regulates PD-L1 and CD47 mRNA and protein expression in tumor cells. Many other oncogene signaling pathways have been shown to regulate PD-L1, which may also occur through MYC.
2021年9月10日 · Herein, we discuss how MYC pathways not only dictate cancer cell pathophysiology but also suppress the host immune response against that cancer. We also propose that therapies targeting the...
MYC, Metabolism, and Cancer | Cancer Discovery | American …
2015年9月30日 · Through its targets, MYC coordinates nutrient acquisition to produce ATP and key cellular building blocks that increase cell mass and trigger DNA replication and cell division. In cancer, genetic and epigenetic derangements silence checkpoints and unleash MYC's cell growth– and proliferation-promoting metabolic activities.
RAS and MYC: Co-conspirators in Cancer - NCI - National Cancer …
Similarly to RAS, MYC lacks druggable structural features that makes direct therapeutic targeting difficult. As such, therapeutic compounds that target the pathways that control MYC expression and/or drive the posttranslational regulation of MYC have emerged as novel cancer therapeutics.
Myc protein: function, pathway and mutation – American …
Myc protien is a transcription factor that activates expression of many genes through binding on consensus sequences (Enhancer Box sequences (E-boxes)) and recruiting histone acetyltransferase (HATs).
MYC and the Pathway to Cancer - CSHL P
The discovery of the MYC oncogene was a major milestone along the road leading to our current understanding of genetic alterations in cancer and how transcription contributes to tumorigenesis.
Dynamic Multilevel Regulation of EGFR, KRAS, and MYC …
2025年1月14日 · MYC gene regulation can be disrupted by a variety of mechanisms, including gene amplification, chromosomal translocation, or alteration of signaling pathways. Excessive activation of the MYC gene by amplification can be observed in breast, pancreatic or lung cancer, while its aberrant influence on signaling pathways such as PI3K/AKT or MAPK is ...
MYC-Driven Pathways in Breast Cancer Subtypes - MDPI
2017年4月25日 · MYC regulates expression of RNA, both protein and non-coding, that control central metabolic pathways, cell death, proliferation, differentiation, stress pathways, and mechanisms of drug resistance. Activation of MYC has been widely reported in …