Bone morphogenetic protein - Wikipedia
Signal transduction through BMPRs results in mobilization of members of the SMAD family of proteins. The signaling pathways involving BMPs, BMPRs and SMADs are important in the development of the heart, central nervous system, and cartilage, as …
Bone Morphogenetic Protein (BMP) signaling in development …
Sep 1, 2014 · Bone Morphogenetic Proteins (BMPs) are a group of signaling molecules that belongs to the Transforming Growth Factor-β (TGF-β) superfamily of proteins. Initially discovered for their ability to induce bone formation, BMPs are …
Bone Morphogenetic Proteins - PMC
BMP signaling plays important roles in adipogenesis, not only in maturation of pre-adipocytes, but also in commitment of undifferentiated progenitor cells.
TGF-β/BMP signaling and other molecular events: regulation of
Apr 14, 2015 · Phosphorylation of TGF-β (I/II) or BMP receptors activates intracellular downstream Smads, the transducer of TGF-β/BMP signals. This signaling is modulated by various factors and pathways,...
The roles and regulatory mechanisms of TGF-β and BMP signaling …
Jan 24, 2024 · TGF-βs and BMPs transduce signals through SMAD-dependent and -independent pathways; specifically, they recruit different receptor heterotetramers and R-Smad complexes, resulting in unique...
BMP signalling in skeletal development, disease and repair
Feb 19, 2016 · In this Review, we describe BMP superfamily signalling in the context of skeletal development and joint morphogenesis, with the premise that the pathway is poised as a promising...
Making sense of BMP signaling complexity - Cell Press
May 18, 2022 · In this issue of Cell Systems, two studies systematically interrogate the Bone Morphogenetic Protein (BMP) pathway, uncovering mechanisms and consequences of distinct responses to combinations of BMP ligands.
The BMP signaling and in vivo bone formation - PMC
Aug 8, 2005 · Studies from transgenic and knockout mice and from animals and humans with naturally occurring mutations in BMPs and their signaling molecules have shown that BMP signaling plays critical roles in bone and cartilage development and postnatal bone formation.
Specification of BMP Signaling - PMC - PubMed Central (PMC)
Bone Morphogenetic Proteins (BMPs) together with the Growth and Differentiation Factors (GDFs) form the largest subgroup of the Transforming Growth Factor (TGF)β family and represent secreted growth factors, which play an essential role in many aspects of cell communication in higher organisms.
Bone morphogenetic protein receptors: Structure, function …
Sep 1, 2020 · Bone morphogenetic proteins (BMPs) are secreted cytokines that control the fate and function of many different cell types. They exert their cellular responses via heteromeric complexes of specific BMP type I and type II serine/threonine kinase receptors, e.g. …
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