Biochemically, this enzyme is involved in the biosynthesis of the adrenal gland hormones aldosterone and cortisol, which are important in blood pressure regulation, sodium homeostasis and blood sugar control.

Biochemistry of CYP21. Steroid 21-hydroxylase (P450c21, CYP21) is a microsomal cytochrome P450 enzyme that converts 17-hydroxyprogesterone to 11-deoxycortisol and progesterone to deoxycorticosterone. As with other microsomal P450s, the enzyme accepts electrons from a NADPH-dependent cytochrome P450 reductase, thus reducing molecular oxygen and ...

Biphasic regulation by N6, 2′-O-dibutyryl adenosine 3′, 5′-cyclic monophosphate (dbcAMP) of steroid 21-hydroxylase activity in rat hepatocytes. The Journal of Steroid Biochemistry and Molecular Biology 1994, 48 (5-6) , 557-561. https://doi.org/10.1016/0960-0760(94)90208-9

CAH traditionally has three forms based on clinical phenotypes: a severe form with a concurrent defect in aldosterone biosynthesis (salt-wasting type) and a form with apparently normal aldosterone biosynthesis (simple virilizing type) together termed classic 21 …

21-Hydroxylase is a cytochrome P450 enzyme and follows the P450 catalytic cycle. 21-Hydroxylase is highly specific for hydroxylation of progesterone and 17-hydroxyprogesterone. No studies have reported sufficient binding of alternate substrates.

Human CYP21A2 (steroid 21-hydroxylase) acts on the side-chain attached to C-17 in ring D of a steroid substrate, but the configuration of ring A also plays a prominent role in substrate cognition.

21-Hydroxylase is a member of the P-450 superfamily of genes involved in the biosynthesis of cortisol and aldosterone in the adrenal cortex. Congenital adrenal hyperplasia, a well-characterized disease, originates from a lack of this enzyme. We present in this report an in situ hybridization study a …

Human cytochrome P450c21 (steroid 21-hydroxylase, CYP21A2) catalyzes the 21-hydroxylation of progesterone (P4) and its preferred substrate 17α-hydroxyprogestrone (17OHP4). CYP21A2 activities, which are required for cortisol and aldosterone biosynthesis, involve the formation of energetically disfavored primary carbon radicals.

The gene encoding 21-hydroxylase is a microsomal cytochrome P450, family 21, subfamily A, polypeptide 21 (CYP21A2) located on the short arm of chromosome 6 within the human leukocyte antigen complex. 50,51 CYP21A2 and its homolog pseudogene CYP21A1P alternate with two genes, C4B and C4A, which encode two isoforms of the fourth component of the ...

2015年8月31日 · Biochemistry. 21-hydroxylase is one of the cytochrome p450 enzymes, which converts 17-hydroxyprogesterone to 11-deoxycortisol and progesterone to deoxycorticosterone. These resulting metabolites represent the precursor of cortisol and aldosterone respectively. 21-OHD leads to reduce the amount of cortisol and aldosterone synthesis.