Mycobacterium vaccae is a nonpathogenic [1] species of the Mycobacteriaceae family of bacteria that lives naturally in soil. Its name originates from the Latin word, vacca (cow), since the first Mycobacterium strain was cultured from cow dung in Austria. [2] .

2019年6月17日 · Mycobacterium vaccae is a non-pathogenic bacterium that lives in soil, and has shown considerable promise in health research; now, a new study may have finally figured out why. The findings suggest that a specific kind of fat inside M. vaccae could be why exposure to this seemingly beneficial bacterium in ground soil may be good for us.

2024年2月5日 · 微卡（Mycobacterium Vaccae）是一种特定的溶菌产物，用母牛分枝杆菌培养后收集的菌体，经高压均质、灭活后加入稳定剂冻干制成，主要有效成份为母牛分枝杆菌菌体蛋白，经药效学研究显示，其具有双向免疫调节功能，作为预防性结核病疫苗开展的3期临床研究已完成。 2021年6月获得国家食品药品监督管理局批准，但是目前该生物制品未被纳入疫苗范畴，属于治疗性生物制品。 多项研究结果显示，注射微卡并接受抗结核治疗的初治、复治和耐多药肺 …

Mycobacterium vaccae NCTC 11659, a Soil-Derived Bacterium with Stress Resilience Properties, Modulates the Proinflammatory Effects of LPS in Macrophages

Mycobacterium vaccae is an environmental saprophyte that is thought to have immunogenic properties that enhance the host's immune response. It is being tested as an adjunct in TB treatment rather than a preventive vaccine and will not be further discussed in this article. Salil Bhargava, ... Satyendra Mishra.

2022年10月14日 · M. vaccae(MV)疫苗由热灭活的母牛分枝杆菌(Mycobacterium vaccae)制成，是一种用于活动性结核病辅助治疗的免疫调节剂。 Gong等在小鼠模型中证明，MV疫苗对肺部MTB感染具有保护作用。

2023年5月1日 · Vaccae™是从非感染性结核分枝杆菌衍生的灭活疫苗，通过热灭活和高压空气剪切实现。 Vaccae™已完成III期临床试验作为预防性结核病疫苗，疫苗可以诱导细胞免疫并减轻过敏炎症反应。

2020年5月13日 · Vaccae疫苗是一种特定的溶菌产物，已被中国食品药品监督管理局批准用作免疫治疗剂，帮助缩短药物敏感结核病患者的疗程。 一项评估其在潜伏结核感染人群中预防结核病的有效性和安全性的III期试验已完成，数据分析正在进行中。

Few studies have examined the potential influence of ambient bacteria, such as Mycobacterium vaccae on the gut-brain-microbiota axis. In this preliminary research, we show that mice fed live M. vaccae prior to and during a maze learning task demonstrated a reduction in anxiety-related behaviors and maze completion time, when tested at three ...

Recent findings demonstrate that treatment with the immunoregulatory and anti-inflammatory bacterium, Mycobacterium vaccae (M. vaccae), attenuates stress-induced exaggeration of peripheral inflammation and stress-induced anxiety-like behavioral responses.