A protein precursor, also called a pro-protein or pro-peptide, is an inactive protein (or peptide) that can be turned into an active form by post-translational modification, such as breaking off a …

Proprotein convertases (PPCs) are a family of proteins that activate other proteins. Many proteins are inactive when they are first synthesized, because they contain chains of amino acids that …

前蛋白转化酶枯草 溶菌素 9（Proprotein convertase subtilisin/kexin type 9，PCSK9）是胆固醇代谢的关键分子，可与细胞表面的 低密度脂蛋白 受体(LDLR)结合,共同转运至溶酶体使后者发生 …

2019年2月19日 · 前蛋白转化酶枯草杆菌蛋白酶/kexin9型(proprotein convertase subtilisin/kexin type 9, PCSK9)抑制剂已获监管机构批准，用于治疗LDL-C下降不充分的患者。 安进公司生产 …

2012年4月20日 · In this Review, we summarize the physiological functions and pathological implications of the proprotein convertases, and discuss proposed strategies to control some of …

Proprotein convertases are now considered to be attractive targets for the development of powerful novel therapeutics. In this Review, we summarize the physiological functions and …

2011年12月29日 · However, another, smaller family of serine proteases — the proprotein convertases — performs a variety of activation functions involving critical cellular pathways in …

These data provide evidence that an inhibitor of PCSK9-LDLR interaction is a viable target for the development of a novel cholesterol lowering drug in conjunction with the classical statins. The …

2019年3月4日 · 前蛋白转化酶枯草溶菌素9（Proprotein Convertase Subtilisin/kexin Type 9，PCSK9）是一种肝细胞合成的丝氨酸蛋白酶，在血液中循环可与低密度脂蛋白受体（Low …

2022年1月7日 · Furin is the first discovered proprotein convertase member and is present in almost all mammalian cells. Therefore, by regulating the maturation of a wide range of …