In biochemistry, a phosphatase is an enzyme that uses water to cleave a phosphoric acid monoester into a phosphate ion and an alcohol. Because a phosphatase enzyme catalyzes the hydrolysis of its substrate, it is a subcategory of hydrolases. [1]

Alkaline phosphatase (ALP) is an enzyme that exists throughout your body. High levels of ALP in your blood may indicate liver disease or certain bone disorders.

2025年2月4日 · The alkaline phosphatase test is a common blood test that helps diagnose liver and bone disorders. Learn about its uses, procedure, and normal range.

An alkaline phosphatase (ALP) test measures the amount of ALP in your blood. ALP is an enzyme, a protein that speeds up certain chemical reactions in your body. ALP is found in all your body tissues, but higher amounts can be found in your liver, bile ducts, and bones.

2024年12月16日 · High alkaline phosphatase levels are an important diagnostic marker for a range of liver, bone, and other systemic conditions. Understanding the diverse causes, recognizing associated symptoms, and employing appropriate diagnostic and treatment strategies narrow the differential diagnosis to employ the proper treatment.

2020年8月20日 · Alkaline phosphatases (ALPs) are a group of isoenzymes located on the outer layer of the cell membrane. They catalyze the hydrolysis of organic phosphate esters found in the extracellular space. Zinc and magnesium are essential cofactors of this enzyme.

The enzyme alkaline phosphatase (ALP, alkaline phenyl phosphatase, also abbreviated PhoA) is a phosphatase with the physiological role of dephosphorylating compounds.

2025年2月17日 · Alkaline phosphatase (ALP) is an enzyme used as a marker for diseases of the liver, bone, and other organs. Low ALP levels can be a sign of thyroid disease, malnutrition, and more.

In this article, you will learn the different levels of alkaline phosphatase in: Adults. Children and adolescents. Pregnant women. Low alkaline phosphatase (lower limits by age) and its cause. The common causes of marked versus mild elevations in alkaline phosphatase. 1. Normal alkaline phosphatase levels charts (by age and gender).

Evaluate the significance of phosphatase dysregulation in diseases such as cancer and metabolic disorders. Discuss strategies for designing selective phosphatase inhibitors and the challenges involved due to the conserved nature of active sites in many phosphatases.