Astrocyte transcriptomic changes along the spatiotemporal …
2024年12月6日 · This was an ambitious study using single-nucleus RNA-Seq to characterize astrocyte heterogeneity across five brain regions in 32 donors who spanned the spectrum of …
Astrocyte Receptor Suppresses Neurotoxic Lipids, Preserves Neurons
2023年9月20日 · Comparing reactive astrocyte RNA-Seq datasets from Alzheimer’s, multiple sclerosis, Huntington’s, amyotrophic lateral sclerosis, frontotemporal lobar degeneration, and …
In Amyloidosis, Ephrin-A4 Goads Astrocytes to Massacre Synapses
2025年3月8日 · As for astrocytes, three subsets emerged. One expressed high levels of EphA4 along with genes involved in astrocyte reactivity, phagocytosis, and synapse elimination. The …
In Amyloidosis, EphA4 Goads Astrocytes to Massacre Synapses
6 天之前 · As for astrocytes, three subsets emerged. One expressed high levels of EphA4 along with genes involved in astrocyte reactivity, phagocytosis, and synapse elimination. The latter …
Astrocytes Mount Complex Responses to AD. They Change Over …
2024年12月5日 · “The coexistence of multiple astrocyte phenotypes suggests that we should address astrocyte heterogeneity, stratify astrocyte subtypes, and consider multiple astrocyte …
Aβ Clearance—The Untapped Potential of Astrocytes? - ALZFORUM
2021年11月9日 · Astrocyte With Appetite. Cultured mouse astrocytes treated with gemfibrozil and retinoic acid (right) ingurgitated more Aβ (white) than did untreated cells (left), and …
Over the Span of AD, Roles of Astrocytes and Microglia Change
First, Bellaver investigated how astrocyte reactivity influenced the relationship between amyloid status, as gauged by PET or plasma Aβ42/40 levels, and plasma p-tau217. She found that …
Old Cytokine, New Tricks? Astrocyte IL-3 Pokes Microglia in AD
2021年7月16日 · More broadly, astrocyte-derived IL3 has been found to be: implicated as a microglial growth factor (Frei et al., 1986); important for neural development (Luo et al., 2012); …
APOE from astrocytes restores Alzheimer's Aβ-pathology and …
2024年12月4日 · Astrocyte-microglia interactions are thought to be central factors driving early AD neuropathology, so the authors first explored the relationship between astrocyte …
ELOVL Hurts—Enzyme Makes Lipids That Turn Astrocytes Toxic
2021年10月8日 · Martin Kampmann University of California, San Francisco; Posted: 08 Oct 2021 In their tour de force study, Guttenplan, Liddelow and colleagues provide compelling evidence …