Thiosemicarbazone - Wikipedia
A thiosemicarbazone is an organosulfur compound with the formula H 2 NC (S)NHN=CR 2. Many variations exist, including those where some or all of the N H centers are substituted by organic groups. Thiosemicarbazones are usually produced by condensation of a thiosemicarbazide with an aldehyde or ketone:
Thiosemicarbazones as Potent Anticancer Agents and their Modes …
TSCs have a wide clinical antitumor spectrum with efficacy in various tumor types such as leukemia, pancreatic cancer, breast cancer, non-small cell lung cancer, cervical cancer, prostate cancer and bladder cancer. To obtain better activity, different series of TSCs have been developed by modifying the heteroaromatic system in their molecules.
Thiosemicarbazone | C10H12N4OS | CID 2733749 - PubChem
Thiosemicarbazone | C10H12N4OS | CID 2733749 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
Thiosemicarbazone - an overview | ScienceDirect Topics
Thiosemicarbazones are a class of synthetic tridentate chelators designed specifically for anti-cancer therapy and have demonstrated potent anti-proliferative efficacy in vitro and in vivo [5,17].
Advances in thiosemicarbazone metal complexes as anti-lung …
In this review, we discuss the potential of thiosemicarbazone Schiff base complexes as anti-lung cancer drugs, their anti-cancer activities and the most likely action mechanisms involving the recent families of copper, nickel, platinum, ruthenium and other complexes.
Thiosemicarbazone-Based Compounds: A Promising Scaffold for …
2024年12月31日 · This paper presents the synthesis and characterization of new thiosemicarbazone derivatives with potential applications as antibacterial, antioxidant and anticancer agents. Six thiosemicarbazone derivatives (L–L5) were synthesized by reacting an appropriate thiosemicarbazide derivative with 2-pyridinecarboxaldehyde.
Versatile biological activities of thiosemicarbazones and their …
Thiosemicarbazone act as chelating agents to form complexes with transition metals. Thiosemicarbazone based complexes possess a broad range of biological activities. Recent developments on the synthesis, characterization, and biological evaluation of thiosemicarbazones and their metal complexes.
Thiosemicarbazone - an overview | ScienceDirect Topics
Thiosemicarbazones are the analogs of the semicarbazides with a sulfur atom in place of the oxygen atom. They are readily prepared by the condensation reaction between a ketone (or aldehyde) and a thiosemicarbazide.
Anticancer Thiosemicarbazones: Chemical Properties, Interaction …
2019年2月1日 · The potent and novel thiosemicarbazone chelators di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone and 2-benzoylpyridine-4,4-dimethyl-3-thiosemicarbazone affect crucial thiol systems required for ribonucleotide reductase activity.
Synthesis and biological evaluation of thiosemicarbazone …
2022年7月21日 · Thiosemicarbazones are compounds obtained by the reaction of thiosemicarbazide with aldehydes and ketones. Due to their biological activities and pharmacological properties, they have been the subject of many studies in recent years.