In this series, seven cases were identified that expressed S-100 protein positive cells. The S-100 positive cells were predominantly large mononuclear and multinucleated histiocytes with eosinophilic cytoplasm, but also in some cases xanthomatous cells and Touton giant cells.

2016年6月2日 · ECD histiocytes are positive for CD68 and CD163 and negative for CD1a. Some histiocytes may be positive for S100 protein. Some biopsies may lack lipid-laden histiocytes, but the presence of fibrosis and few “peculiar” histiocytes will favor the diagnosis.

2023年11月2日 · LCH is defined by the presence of CD1a + /CD207 + histiocytes. Although usually positive for S-100, rare S-100 negative variants have been reported in skin-limited LCH and LC-Sarcoma. An aberrant maturation process was proposed as a possible explanation, but the exact pathology remains unknown.

The Hodgkinoid histiocytes occasionally showed emperipolesis. They expressed CD30, S100, and PD-L1 proteins but lacked PAX5 and CD1a expressions, Epstein-Barr association, BRAF V600E mutation, and PD-L1 gene amplification. Neither of the patients showed overt progression to malignant haematopoietic neoplasms during the disease course.

CD1a -positive, S-100-negative Langerhans cell histiocytosis (LCH) is a rare variant of LCH that has just come to recognition within the past three years. This novel entity is characterized by immunotypical features of both monocyte- and/or macrophage-differentiated and Langerhans-differentiated cells.

Histiocytic cells with S100 protein compose a cell lineage independent of the monocyte-macrophage system. Langerhans cells and indeterminate cells in the skin and oral mucosa, interdigitating cells in the T-zone of the lymph node, and other lymphoid tissues belong to …

S100 protein is a calcium-flux determinant that is expressed by normal melanocytes, Langerhans histiocytes, cartilaginous cells, adipocytes, Schwann cells, astrocytes, oligodendroglia, ependyma, eccrine sweat glands, reticulum cells, salivary glands, and myoepithelial cells [46-49].

2021年6月14日 · An immunohistochemistry panel including CD163, CD1a, langerin, S100, Factor XIIIa, OCT2, and BRAF V600E can provide definitive diagnosis in LCH and RDD, whereas ECD requires classic clinical features as well as confirmation of an activating MAPK pathway mutation by genetic studies.

On occasion, the histiocytes may have a signet ring appearance, which may be mistaken for metastatic signet ring carcinoma or melanoma; however, the distinction is easily made by immunohistochemistry and special stains, as the histiocytes are positive with CD68 and negative for cytokeratin, S100 and mucin stains, although they may contain ...

2022年7月5日 · The Hodgkinoid histiocytes occasionally showed emperipolesis. They expressed CD30, S100, and PD-L1 proteins but lacked PAX5 and CD1a expressions, Epstein–Barr association, BRAF V600E mutation, and PD-L1 gene amplification. Neither of the patients showed overt progression to malignant haematopoietic neoplasms during the disease course.