2021年3月30日 · Here, we review the current understanding of programmed cell death. We focus on apoptosis, necroptosis, and pyroptosis and on how these processes regulate the immune response.

2023年12月18日 · During apoptosis, a cascade of caspase activation mediates signal transduction and cellular destruction, whereas pyroptosis occurs when activated caspases cleave gasdermins, which can then form...

Pyroptosis is a highly inflammatory form of lytic programmed cell death that occurs most frequently upon infection with intracellular pathogens and is likely to form part of the antimicrobial response.

Pyroptosis is a pathway to cell death mediated by the activation of caspase-1, a protease that also activates the inflammatory cytokines, IL-1β, and IL-18. This pathway is therefore inherently proinflammatory. Pyroptosis also features cell lysis and release of inflammatory cellular contents.

In the context of cancer, the proliferation of cancer cells can be inhibited by inducing cancer cell pyroptosis. Apoptosis is a programmed cell death, mediated by specific proteins encoded by the host genome to eliminate single cells from living tissue.

2022年2月28日 · A simple model of the biological relevance of apoptosis, pyroptosis, and necroptosis distinguishes them by stipulating that apoptosis works to maintain normal development and tissue homeostasis, while pyroptosis …

2024年1月4日 · The release of cytochrome c from mitochondria activates apoptosis, whereas the resulting breakdown of the mitochondrial ETC generates ROS, possibly contributing to ferroptosis. Treatment with common chemotherapy compounds induces caspase-9-mediated apoptosis and activates GSDME, which turns on pyroptosis. 62

Here, we summarize the latest discoveries in the three most well understood modalities of cell death, namely, apoptosis, necroptosis, and pyroptosis, highlighting common and unique pathways and their effect on the surrounding cells and the organism as a whole.

This enhanced sensitivity to pyroptosis allows a shift from the non- or anti-inflammatory modes of cell death triggered by Yersinia and Francisella in naive macrophages (apoptosis and autophagy, respectively) to inflammatory pyroptosis .

Here, we summarize the latest discoveries in the three most well understood modalities of cell death, namely, apoptosis, necroptosis, and pyroptosis, highlighting common and unique pathways and...