- The chemical structure of prolactin is similar to the structure of growth and placental lactogen hormones. Together, they form the "prolactin/growth hormone/placental lactogen" family, which is characterized by a conserved helix bundle protein composition.pubmed.ncbi.nlm.nih.gov/29939606/
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See all on WikipediaProlactin - Wikipedia
The structure of prolactin is similar to that of growth hormone and placental lactogen. The molecule is folded due to the activity of three disulfide bonds. Significant heterogeneity of the molecule has been described, thus bioassays and immunoassays can give different results due to differing … See more
Prolactin (PRL), also known as lactotropin and mammotropin, is a protein best known for its role in enabling mammals to produce milk. It is influential in over 300 separate processes in various vertebrates, including humans. Prolactin … See more
In humans
Prolactin has a wide variety of effects. It stimulates the mammary glands to produce milk (lactation): increased serum concentrations of prolactin during pregnancy cause enlargement of the mammary glands … See moreProlactin receptors are present in the mammillary glands, ovaries, pituitary glands, heart, lung, thymus, spleen, liver, pancreas, See more
The serum concentration of prolactin can be given in mass concentration (μg/L or ng/mL), molar concentration (nmol/L or pmol/L), or international units (typically mIU/L). The current IU is calibrated against the third International Standard for Prolactin, IS 84/500. … See more
In humans, prolactin is produced at least in the anterior pituitary, decidua, myometrium, breast, lymphocytes, leukocytes and prostate.
Pituitary See moreProlactin levels may be checked as part of a sex hormone workup, as elevated prolactin secretion can suppress the secretion of follicle stimulating hormone and gonadotropin-releasing hormone, leading to hypogonadism and sometimes causing See more
General guidelines for diagnosing prolactin excess (hyperprolactinemia) define the upper threshold of normal prolactin at 25 μg/L for women and 20 μg/L for men. Similarly, guidelines … See more
Wikipedia text under CC-BY-SA license Prolactin: structure, function, and regulation of secretion
Prolactin is a protein hormone of the anterior pituitary gland that was originally named for its ability to promote lactation in response to the suckling stimulus of hungry young mammals. We now …
- Author: Marc E. Freeman, Béla Kanyicska, Anna Lerant, György Nagy
- Publish Year: 2000
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Physiology, Prolactin - StatPearls - NCBI Bookshelf
Prolactin is a polypeptide hormone responsible for lactation, breast development, and hundreds of other actions needed to maintain homeostasis. The chemical structure of prolactin is similar to …
Prolactin: Structure, Function, and Regulation of Secretion
Jan 10, 2000 · In this review we integrate the burgeoning information on prolactin's structure (sect. ii), synthesis and release from varying sources (sect. iii), the intracellular mechanism of its …
Prolactin Biology and Laboratory Measurement: An Update on …
Prolactin is a 23 kDa single chain protein of 199 amino acids synthesised and released principally by lactotrophs in the anterior pituitary gland. The secretion is mainly under inhibitory control by …
Prolactin: structure, receptors, and functions | Reviews in ... - Springer
Oct 30, 2024 · Prolactin (PRL) is a 23-kDa protein synthesized and secreted by lactotroph cells of the anterior pituitary gland but also by other peripheral tissues.
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Prolactin: structure, receptors, and functions - PubMed
Oct 30, 2024 · Prolactin (PRL) is a 23-kDa protein synthesized and secreted by lactotroph cells of the anterior pituitary gland but also by other peripheral tissues.
Prolactin: Structure, Function, and Regulation of Secretion. Physiol Rev 80: 1523–1631, 2000.—Prolactin is a protein hormone of the anterior pituitary gland that was originally named …
1RW5: Solution structure of human prolactin - RCSB PDB
Dec 16, 2003 · We report the solution structure of human prolactin determined by NMR spectroscopy. Our result is a significant improvement over a previous structure in terms of number and distribution of distance restraints, regularity …
Prolactin (PRL) is a 23-kDa protein synthesized and secreted by lactotroph cells of the anterior pituitary gland but also by other peripheral tissues. PRL binds directly to a unique …
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