2021年10月22日 · By using iridium catalyst C3b with a chiral spiro phosphine-oxazoline ligand (SIPHOX), a wide variety of chiral amines P29 were attained in excellent yields and enantioselectivities via direct catalytic AH of 2-pyridyl cyclic imines S29 .

3 天之前 · Utilizing novel chiral diamine-derived pyrroles and primary amines as catalysts, we successfully synthesized a diverse range of triarylmethanes with high yields and excellent enantioselectivities. This method not only exhibits a broad substrate scope and outstanding functional group tolerance but also enables the precise synthesis of deuterated ...

2023年4月10日 · This tutorial review highlights the state-of-the-art catalytic methods for the direct asymmetric synthesis of α-chiral primary amines and demonstrates their utility in the construction of molecular complexities, which may attract extensive attention and inspire applications in synthetic and medicinal chemistry.

2020年7月15日 · α-Chiral primary amines are one among the most valuable and versatile building blocks for the synthesis of numerous amine-containing pharmaceuticals and natural compounds. They also serve as chiral ligands or organo-catalysts for asymmetric catalysis.

2008年4月18日 · The authors proposed the direct asymmetric Mannich reactions catalyzed by chiral primary amine and amino acid occurred via the six-membered chair-like transition states I and II, respectively, for which the si-face of the catalytically generated chiral enamine is approached by the si-face of the in situ generated acceptor imine (Fig. 6).

2021年12月3日 · Here we developed a proof-of-concept bi-enzymatic cascade, consisting of an ene reductase and amine dehydrogenase (AmDH), to afford chiral diastereomerically enriched amines in one pot. The asymmetric reduction of unsaturated ketones and aldehydes by ene reductases from the Old Yellow Enzyme family (OYE) was adapted to reaction conditions for ...

2024年10月16日 · Detection of chiral molecules in a high-efficiency way is very important to meet the demands for chiral analysis in drug testing, asymmetric synthesis, etc. Herein, we have developed a novel route to realize the rapid determination of concentration and configuration of primary amine-based chiral molecules. An aldehyde functionalized acid & base ...

In the past few years, primary amine catalysts derived from natural amino acids, Cinchona alkaloids and other chiral amines have emerged as readily available, highly versatile and extremely powerful catalysts in asymmetric synthesis.

2020年5月5日 · Chiral primary amines are important intermediates in the synthesis of pharmaceutical compounds. Fungal reductive aminases (RedAms) are NADPH-dependent dehydrogenases that catalyse reductive amination of a range of ketones with short-chain primary amines supplied in an equimolar ratio to give corresponding se

2005年11月28日 · A general preparation of functionalized primary chiral amines and amides from propargylamines has been developed. The chirality is established by an enantioselective three-component reaction of an aldehyde, a terminal alkyne and a secondary amine in the presence of copper(I) bromide/Quinap as the catalytic system leading to chiral ...