卤代咔唑衍生物(Polyhalogenated carbazoles，PHCZs)是新涌现的卤代杂环芳香烃类有机污染物，其结构类似于多氯代二苯并呋喃(Polychlorinated dibenzofurans，PCDFs)。科学家们陆续在北美、欧洲和亚洲的多种环境样品中检出了PHCZs。 ... 但是AhR基因沉默仅对2367-CCZ诱导 …

卤代咔唑(polyhalogenated 9H-carbazoles，PHCs)是指咔唑环上的氢原子被卤素原子(Cl、 Br或I)所取代的一类化合物. 从化学结构上看，PHCs与多氯二苯并呋喃(polychlorinated dibenzofuran，PCDFs)具有相似的结构.

The structure-dependent induction of CYP1A1 and CYP1B1 gene expression in Ah-responsive MDA-MB-468 breast cancer cells by these carbazoles was similar to that observed for other dioxin-like compounds, and the magnitude of the fold induction responses for the most active halogenated carbazoles was similar to that observed for 2,3,7,8 ...

2022年10月1日 · Polyhalogenated carbazoles (PHCZs) are widely present in the environment, and their health risks are of increasing concern. Available studies primarily confirm their dioxin-like toxicity mechanism based on biomarkers, such as aryl hydrocarbon receptor (AHR) and CYP1A1, while few studies have investi …

2019年10月15日 · The most potent AhR-activating PHCZ identified here, 2367-CCZ, had the most potent induction effect on CYP1A1 gene expression, which was mostly (95%) reversed after AhR silencing (Fig. S7). Generally, PHCZs with higher REP values induced CYP1A1 expression in higher degrees (Fig. 2).

2018年1月1日 · Polyhalogenated carbazoles (PHCs) are a class of emerging organic contaminants that have received increasing concern due to their widespread distribution and dioxin-like toxicity. Although previous studies have suggested possible natural sources of PHCs in the environment, the formation pathways are poorly understood.

2019年10月15日 · In this study, eleven PHCZs, including four chlorocarbazoles, four bromocarbazoles and two bromo/chlorocarbazoles were screened for their potential aryl hydrocarbon receptor (AhR) activity by using a dioxin responsive element-driven luciferase reporter assay. We found that nine PHCZs significantly activated AhR in a concentration-dependent manner.

现有研究主要基于芳烃受体 (ahr) 和 cyp1a1 等生物标志物证实了它们的二恶英样毒性机制，而很少有研究调查它们在个体生物水平上的实际毒性作用。

2019年10月15日 · Polyhalogenated carbazoles (PHCZs) are a class of contaminants identified with persistence and bioaccumulation property from previous studies. However, the toxic effect and mechanism of PHCZs are not fully understood. In this study, eleven PHCZs, including four chlorocarbazoles, four bromocarbazoles …

2025年1月31日 · 卤代咔唑（Polyhalogenated carbazoles，PHCZs）是类二恶英的新污染物。 在土壤和沉积物等介质中检出。 PHCZs具有持久性、生物蓄积性、发育毒性、内分泌干扰和神经毒性，引起了广泛的公众关注。