Octenidine dihydrochloride is a cationic surfactant, with a gemini-surfactant structure, derived from 4-aminopyridine. It is active against Gram-positive and Gram-negative bacteria. Since 1987, it has been used primarily in Europe as an antiseptic prior …

Octenidine dihydrochloride is an effective antiseptic compound for skin mucous membranes and wounds.

奥替尼啶通过在作用点与细胞毒素结合而发挥活性，对 革兰氏阳性菌 、阴性菌和真菌都具有很好的抗菌作用，并且这种抗菌能力不受干扰物（如血液，粘液）影响。 此外，奥替尼啶在皮肤表面有很强的残存效应，应用24小时后仍可以观察到其抗菌效应。 抗菌能力方面，奥替尼啶对金黄色葡萄球菌， 表皮葡萄球菌， 变形杆菌， 化脓性链球菌， 肺炎克雷伯菌， 大肠杆菌 和 白色念珠菌 等的效力优于4%洗必泰。 它 （C＜1.5μM）在15分钟内使这些细菌的数量减少99%。 然而，伤口 …

Octenidine dihydrochloride (octenidine) was introduced for skin, mucous membrane and wound antisepsis more than 20 years ago. Until now, a wealth of knowledge has been gained, including in vitro and animal studies on efficacy, tolerance, safety and clinical experience both from case reports and pros …

This article summarises the physical, chemical and antimicrobial properties of OCT in the context of wound care. Keywords: Octenidine dihydrochloride; antimicrobial efficacy; biocompatibility index; biofilm; contraindications; cytotoxicity; wound antisepsis.

Background: The antiseptic agent octenidine dihydrochloride (OCT) is used for skin preparation, for Staphylococcus aureus decolonization, and within bundles for the prevention of catheter-related or surgical site infections (SSIs). Here, we review …

2024年12月4日 · Octenidine HCl is a bispyridine derivative, characterized by two pyridine rings connected by a flexible aliphatic chain. This structure allows it to interact efficiently with microbial cell membranes, disrupting bacterial and fungal cell walls and leading to cell death.

The active ingredient octenidine Octenidine dihydrochloride as a cation-active ingredient is characterized by a pronounced efficacy which is retained even after the actual application and thus continues to keep superficial bacterial colonization low or reduces it further.

Octenidine dihydrochloride compared favorably with chlorhexidine digluconate with respect to overall antiplaque potency in this in vitro plaque bactericidal model. These data indicate that prudent selection of treatment concentration and duration and frequency of exposure should provide an effective means to aid in controlling dental caries and ...

2023年7月1日 · Objective: Octenidine dihydrochloride is an antimicrobial cationic surfactant compound. We conducted a systematic review to determine the efficacy of octenidine-based mouthwash on plaque...