N-Acetylmuramic acid (NAM or MurNAc) is an organic compound with the chemical formula C 11 H 19 NO 8. It is a monomer of peptidoglycan in most bacterial cell walls, which is built from alternating units of N-acetylglucosamine (GlcNAc) and N-acetylmuramic acid, cross-linked by oligopeptides at the lactic acid residue of MurNAc.

N-acetyl-D-muramic acid is the pyranose form of N-acetylmuramic acid. It is functionally related to a 2-amino-3-O-[(R)-1-carboxyethyl]-2-deoxy-D-glucopyranose. It is a conjugate acid of a 2-acetamido-3-O-[(1R)-1-carboxylatoethyl]-2-deoxy-D-glucopyranose.

2012年2月3日 · Peptidoglycan is composed of the repeating amino sugars, N-acetylglucosamine (NAG) and N-acetylmuramic acid (NAM), cross-linked by peptide bridges. Lysozyme hydrolyzes the bonds between NAG and NAM, which increases the bacterial permeability, leading the bacteria to burst.

The N-acetylmuramic acid component of the bacterial cell wall is derived from N-acetylglucosamine by the addition of a lactic acid substituent derived from phosphoenolpyruvate. Fosfomycin blocks this reaction by inhibiting the pyruvyl transferase enzyme involved.

N-acetylmuramic acid is an important component of the bacterial cell wall, specifically found in the peptidoglycan layer. It is a derivative of the monosaccharide N-acetylglucosamine and plays a crucial role in the structural integrity and function of the bacterial cell wall.

The MurNAc etherase MurQ of Escherichia coli is essential for the catabolism of the bacterial cell wall sugar N-acetylmuramic acid (MurNAc) obtained either from the environment or from the endogenous cell wall (i.e., recycling).

2018年8月1日 · Uridine diphosphate N-acetyl muramic acid (UDP NAM) is a critical intermediate in bacterial peptidoglycan (PG) biosynthesis. As the primary source of muramic acid that shapes the PG backbone, modifications installed at the UDP NAM intermediate can be used to selectively tag and manipulate this polym …

2021年5月7日 · Acetylmuramic acid, N- | C11H19NO8 | CID 7058171 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.

2018年7月9日 · Uridine diphosphate N-acetyl muramic acid (UDP NAM) is a critical intermediate in bacterial peptidoglycan (PG) biosynthesis. As the primary source of muramic acid that shapes the PG backbone, modifications installed at the UDP NAM intermediate can be used to selectively tag and manipulate this polymer via metabolic incorporation.

It is a monomer of peptidoglycan in most bacterial cell walls, which is built from alternating units of N-acetylglucosamine (GlcNAc) and N -acetylmuramic acid, cross-linked by oligopeptides at the lactic acid residue of MurNAc. Quick Facts Names, Identifiers ...