Microglia are a type of glial cell located throughout the brain and spinal cord of the central nervous system (CNS). [1] Microglia account for about 10–15% of cells found within the brain. [2] As the resident macrophage cells, they act as the first and main …

2024年11月21日 · Microglia are a type of glial cell which are essential for the defense mechanisms in the central nervous system (CNS). Microglia share structural and functional similarities with tissue macrophages, highlighting their role in immune responses within the CNS.

Microglia are resident cells of the brain that regulate brain development, maintenance of neuronal networks, and injury repair. Microglia serve as brain macrophages but are distinct from other tissue macrophages owing to their unique homeostatic phenotype and tight regulation by the central nervous system (CNS) microenvironment.

2024年12月11日 · Microglia, type of neuronal support cell (neuroglia) in the central nervous system of invertebrates and vertebrates that mediates immune responses by acting as macrophages, clearing cellular debris and dead neurons from nervous tissue through the process of phagocytosis (cell eating).

Here, we review the manifold functions of microglia in the brain under physiological and pathological conditions, primarily focusing on the implication of microglia in glioma propagation and progression.

As an immune cell in the central nervous system (CNS), microglia release reactive oxygen products and inflammatory molecules.

2017年4月26日 · In this article, we review recent advances in our understanding of the biology of microglia, their contribution to homeostasis, and their involvement in neurodegeneration. Moreover, we highlight the complexity of targeting microglia for therapeutic intervention in neurodegenerative diseases.

2021年10月12日 · Here, we summarize the latest evidence demonstrating how these interactions drive microglia immune and non-immune functions, which coordinate the transition from homeostatic to disease-related cellular states.

Microglia cells are the immune cells of the central nervous system and consequently play important roles in brain infections and inflammation. Recent in vivo imaging studies have revealed that in the resting healthy brain, microglia are highly …

2018年9月11日 · Microglia are the primary innate immune cells in the CNS. In the healthy brain, they exhibit a unique molecular homeostatic ‘signature’, consisting of a specific transcriptional profile and...