MG132 is a potent, reversible, and cell-permeable proteasome inhibitor [1] (K i = 4 nM). It belongs to the class of synthetic peptide aldehydes. [2] [3] It reduces the degradation of ubiquitin …

2016年8月31日 · MG-132 (Z-Leu-Leu-Leu-al) is a potent proteasome and calpain inhibitor with IC50 s of 100 nM and 1.2 μM, respectively. MG-132 effectively blocks the proteolytic activity of …

We found that MG132 could effectively reverse skeletal muscle atrophy and inhibit tumor growth, accompanied by downregulation of the NF-κB/ubiquitin–proteasome pathway. MG132 is a …

Proteasome inhibitor MG132 exhibits cytotoxic effects and inhibits the migration and invasion of pancreatic cancer cells. After 48 h of treatment, the IC 50 values of MG132 in PANC-1 and …

MG-132 is a potent proteasome and calpain inhibitor. Research studies have shown that MG-132 prevents degradation of the proteasome substrates SucLLVY-MCA and ZLLL-MCA with an IC …

The proteasome inhibitor, MG‑132, was used to induce autophagy in MCF‑7 cells, and 3‑methyladenine (3‑MA) and salubrinal were used to inhibit autophagy and ER stress, …

2025年2月11日 · MG-132 is a well-studied proteasome inhibitor known for its ability to effectively bind to the proteasome, obstructing its activity. Its peptide aldehyde structure allows it to …

MG132. Carbobenzoxy-l-leucyl-l-leucyl-l-leucinal (MG132) is a peptide aldehyde proteasome inhibitor, impeding tumor progression through inactivating NF-κB signaling. In breast cancer …

The peptide-aldehyde proteasome inhibitor MG132 (carbobenzoxyl-L-leucyl-L-leucyl-L-leucine) induces the apoptosis of cells by a different intermediary pathway. Although the pathway of …

MG-132 is a peptide aldehyde (Z-Leu-Leu-Leu-al) that selectively blocks the proteolytic activity of the 26S proteasome. The 26S proteasome is a large protease complex that degrades …