2017年8月15日 · Here we show that Lyn and Fyn control immune receptor signaling status. SHP-1 tyrosine 536 phosphorylation by Lyn activates the phosphatase promoting inhibitory signaling through the...

Signaling through CCR5 in primary human macrophages depends on Lyn kinase, since peptide mediated inhibition of Lyn results in reduced Erk activation following MIP-1β stimulation of macrophages . Similarly, knockdown of Lyn in monocytes using siRNA decreases SDF-1α-mediated migration through monolayers of endothelial cells ( 51 ).

2022年6月9日 · We found that sorafenib inhibited the phosphorylation of tyrosine kinase Lyn induced by LPS, thereby reducing the phosphorylation level of p38 and JNK, inhibiting the …

1998年10月21日 · Untreated macrophages showed a basal level of lyn expression which was significantly enhanced upon cisplatin treatment of macrophages. Cisplatin-induced up-regulation of lyn expression was observed within 5 min of treatment which peaked at 15 min. Sixty min of cisplatin treatment to macrophages resulted in a decline in the lyn expression as ...

2016年10月10日 · Using a well-established mouse model for CLL, we show that LYN kinase, a central molecule of BCR signaling, is important for the pathogenesis of CLL in an intact organism that allows for specific modulation of leukemic and microenvironmental cells.

2016年12月16日 · The pleiotropic Src kinase Lyn has critical roles in host defense in alveolar macrophages against bacterial infection, but the underlying mechanism for Lyn-mediated inflammatory response...

2015年10月30日 · Inflammatory priming of macrophages upregulated LynA and promoted receptor-independent signaling. In contrast, clustering the hemi-ITAM receptor Dectin-1 induced signaling that did not require LynA or inflammatory priming.

2017年4月4日 · To verify our findings on the roles of individual Lyn domains in LPS-stimulated primary macrophages, we used nucleofection to introduce DNA encoding Lyn WT and its mutated forms in thioglycolate-elicited murine peritoneal macrophages.

The reduced tyrosine phosphorylation observed in lyn − / − macrophages compared with hck − / −fgr − / − cells suggests that, of the three principal Src family kinases expressed in macrophages, Lyn plays the dominant role in FcγR signal transduction, including initiation of Syk phosphorylation. However, lack of this kinase alone was ...

2023年12月14日 · Recent studies have established a role for oxPLs in alveolar scarring, and we hypothesized that uptake and accrual of oxPL by CD36 would cause a macrophage phenotypic change that promotes fibrosis. To test this hypothesis, we treated wild-type and CD36-null mice with the oxPL derivative oxidized phosphocholine (POVPC) and found that CD36-null ...