FZD5 controls intestinal crypt homeostasis and colonic Wnt …
2024年11月22日 · Mu et al. identify FZD5 as a critical regulator of intestinal stem cells and crypt homeostasis, underscoring its importance in potential therapeutic interventions for intestinal …
Wnt specifically induces FZD5/8 endocytosis and degradation and …
3 天之前 · Figure 1. Wnt induces FZD5/8 endocytosis and degradation. (A) Wnt3a or Wnt5a specifically reduced the cell surface levels of V5-FZD5/8. HEK293A cells stably expressing …
Next-Generation Surrogate Wnts Support Organoid Growth …
2020年11月5日 · Administration of Fzd subtype-specific NGS Wnt in vivo reveals that adult intestinal crypt proliferation can be promoted by agonism of Fzd5 and/or Fzd8 receptors, while …
FZD5 regulates cellular senescence in human mesenchymal stem/stromal cells
Although mesenchymal stem/stromal cells (MSCs) are promising for cell therapy, long‐term culture leads to MSC senescence with reduced stem cell capacity. We showed that FZD5, …
FZD5 controls intestinal crypt homeostasis and colonic Wnt …
2024年11月22日 · Here, an epithelial-specific Fzd5 knockout (KO) elicited lethal pan-intestinal crypt and villus loss, whereas an Lgr5+ ISC-specific Fzd5 KO depleted Lgr5+ ISCs via …
Frizzled receptors (FZDs) in Wnt signaling: potential therapeutic ...
2024年4月17日 · In HNSCC, FZD8 is highly expressed in cancer stem cells (CSCs) and is a crucial mediator of c-Met-maintained HN-CSCs, which are responsible for the recurrence and …
FZD5 controls intestinal crypt homeostasis and colonic Wnt
2024年11月24日 · KO of Fzd5, not Fzd8, in enteroids ablated responsiveness to dual-specificity FZD5/FZD8-selective Wnt surrogate agonists, which ameliorated DSS-induced colitis in wild …
Single-cell transcriptomics identifies a WNT7A-FZD5 ... - Cell Press
We genetically label, isolate, and characterize putative FT stem cells using functional approaches as well as bulk and SCT analyses, identifying a hormonally regulated WNT7A-FZD5 signaling …
FZD5 regulates cellular senescence in human mesenchymal stem/stromal cells
2020年12月20日 · We found that the transcription factor Frizzled 5 (FZD5) is expressed specifically in immature hMSCs. The FZD5 cell surface antigen was also highly expressed in …
WNT signaling in stem cell biology and regenerative medicine
FZD1, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, FZD10, LRP5, LRP6, and ROR2 are transmembrane receptors transducing WNT signals based on ligand-dependent …
- 某些结果已被删除