The Fries rearrangement, named for the German chemist Karl Theophil Fries, is a rearrangement reaction of a phenolic ester to a hydroxy aryl ketone by catalysis of Lewis acids. [1] [2] [3] [4] It involves migration of an acyl group of phenol ester to the aryl ring.

The Fries Rearrangement enables the preparation of acyl phenols. The reaction is catalyzed by Brønsted or Lewis acids such as HF, AlCl 3, BF 3, TiCl 4 or SnCl 4. The acids are used in excess of the stoichiometric amount, especially the Lewis acids, since they form complexes with both the starting materials and products.

Fries Rearrangement is an organic rearrangement reaction in which an aryl ester is transformed into a hydroxy aryl ketone with the help of a Lewis acid catalyst and an aqueous acid. In this reaction, an acyl group belonging to the phenolic ester migrates to the aryl ring.

Definition: What is Fries Rearrangement? The Fries rearrangement is an organic reaction used to convert a phenyl ester to a hydroxy aryl ketone using a Lewis acid catalyst and Brønsted acid work-up.

The Fries Rearrangement is an organic chemistry rearrangement reaction in which an aryl ester is transformed to a hydroxy aryl ketone with the help of aqueous acid and AlCl 3 catalyst. An acyl group of the phenolic ester is transferred to the aryl ring during the Fries Rearrangement reaction.

2023年5月23日 · The Fries Rearrangement is an organic rearrangement reaction that uses a Lewis acid catalyst and aqueous acid to convert an aryl ester into a hydroxy aryl ketone. An acyl group from the phenolic ester moves from the phenolic ester to the aryl ring in this process.

Fries rearrangement has been employed in the key steps in the total synthesis of muricadienin, the unsaturated putative precursor in the biosynthesis of trans- and cis-solamin. 10 The anionic phospho-Fries rearrangement of chiral ferrocenyl phosphates yields diastereomeric enriched 1,2- P , O -phosphonates, which can then be converted into an ...

Fries Rearrangement is an organic rearrangement reaction that converts an aryl ester into a hydroxy aryl ketone using a Lewis acid catalyst and aqueous acid. It is named after Karl Theophil Fries, a German chemist. In this process, a acyl group from the …

Fries Rearrangement is a rearrangement reaction of organic chemistry in which an aryl ester is converted to a hydroxy aryl ketone with the assistance of aqueous acid and a Lewis acid catalyst. In Fries Rearrangement reaction, an acyl group of …

There are two main types of Fries rearrangement: an anionic reaction where ortho-lithiated O-aryl carbamates are converted to substituted salicylamides, and a photochemical reaction where light-irradiated phenolic esters are converted to the corresponding phenols.