Folate receptor 1 (Folate receptor alpha, FOLR1) is a protein that in humans is encoded by the FOLR1 gene. [5][6] The protein encoded by this gene is a member of the folate receptor …

In this review, we summarize the role of FRα in cancer development, we consider FRα as a potential diagnostic and prognostic tool, and we discuss different targeted treatment …

2020年3月9日 · Folate receptor α (FRα) came into focus as an anticancer target many decades after the successful development of drugs targeting intracellular folate metabolism, such as …

2023年11月26日 · FR is a membrane-bound glycosyl-phosphatidylinositol (GPI) anchor glycoprotein encoded by the folate receptor 1 (FOLR1) gene. FR plays a significant role in …

2006年7月15日 · Folate receptor alpha (FRalpha) is a membrane-bound protein with high affinity for binding and transporting physiologic levels of folate into cells. Folate is a basic component …

Folate receptor alpha (FRα) is cysteine-rich cell-surface glycoprotein that binds folate with high affinity to mediate cellular uptake of folate.

2024年1月15日 · FR is a membrane-bound glycosyl-phosphatidylinositol (GPI) anchor glycoprotein encoded by the folate receptor 1 (FOLR1) gene. FR plays a significant role in …

In this review, we discuss the role of folate receptor alpha (FRα) in EOC development and its potential application as a biomarker and molecular target in designing new EOC screening and …

In this Review, we describe the current status of research into FRα in cancer, including data from several late-phase clinical trials involving FRα-targeted therapies, and the use of new …

2023年2月1日 · Though the role of folate as a causative versus protective agent in carcinogenesis is debated, several studies have indicated that the folate receptor (FR), notably subtype folate …

One potential target is the alpha isoform of the folate receptor (FR), which is selectively overexpressed in several tumor types, including ovarian cancer and nonsmall-cell lung cancer …

2023年6月4日 · Specifically, FR alpha has been found to be an ideal target for ovarian cancer, according to Moore. FR alpha is a cell surface folate receptor that mediates folate transport …

2016年8月9日 · In this review, we summarize the role of FRα in cancer development, we consider FRα as a potential diagnostic and prognostic tool, and we discuss different targeted treatment …

Folate receptor α binds folic acid with high affinity and is involved in folate transport. This is quite relevant in gynecologic malignancy because this receptor is overexpressed in more than 90% …

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2023年8月30日 · In this review, we summarize the function of FRα, and clinical efficacies of various FRα-based therapeutics. We highlight mirvetuximab soravtansine (MIRV), or Elahere …

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