Pathophysiology of diabetes: An overview - PMC - PubMed …
Diabetes mellitus is a chronic heterogeneous metabolic disorder with complex pathogenesis. It is characterized by elevated blood glucose levels or hyperglycemia, which results from abnormalities in either insulin secretion or insulin action or both.
Pathophysiology of Type 2 Diabetes Mellitus - PMC - PubMed …
Type 2 Diabetes Mellitus (T2DM), one of the most common metabolic disorders, is caused by a combination of two primary factors: defective insulin secretion by pancreatic β-cells and the inability of insulin-sensitive tissues to respond appropriately to insulin.
Pathogenesis of Type 2 Diabetes Mellitus - Endotext - NCBI Bookshelf
2021年9月27日 · Numerous distinct pathophysiologic abnormalities have been associated with type 2 diabetes mellitus (T2DM). It is well established that decreased peripheral glucose uptake (mainly muscle) combined with augmented endogenous glucose production are characteristic features of insulin resistance.
Diabetes mellitus: From molecular mechanism to pathophysiology …
2023年9月1日 · The pathophysiology of type 2 diabetes mellitus is distinguished by insulin deficiency and insulin resistance, which have been linked to inflammatory cytokines in the plasma and high levels of fatty acids, leading to deficient glucose transport into target cells, elevated breakdown of fat, and increased hepatic glucose production [29 ...
Type 2 diabetes mellitus in adults: pathogenesis, prevention and ...
2024年10月2日 · Type 2 diabetes (T2D) is a disease characterized by heterogeneously progressive loss of islet β cell insulin secretion usually occurring after the presence of insulin resistance (IR) and it is...
Diabetes - StatPearls - NCBI Bookshelf - National Center for ...
2020年1月3日 · Describe the pathophysiology of diabetes mellitus. Outline the epidemiology and risk factors of diabetes mellitus. Review the treatment considerations and common complications of diabetes mellitus.
Pathophysiology of Diabetes - an overview - ScienceDirect
In this review, we give an overview of the unique pathophysiology of CAD in patients with diabetes, summarize the current state of therapies available, and compare modalities of revascularization that have been investigated in recent clinical trials.
The Pathogenesis of Diabetes - PMC - PubMed Central (PMC)
Understanding the molecular processes involved in the development of diabetes can provide clinical care with much-needed updates. This review provides the current global state of diabetes, the mechanisms involved in glucose homeostasis and diabetic insulin resistance, and the long-chain non-coding RNA (lncRNA) associated with diabetes.
Mechanisms underlying the pathophysiology of type 2 diabetes…
2022年2月1日 · Redox imbalance and oxidative stress are implicated in Type 2 diabetes pathogenesis. Type 2 diabetes development involves a vicious cycle of complex metabolic alterations. Mitochondrial dysfunction and disturbances in insulin signaling are crucial in T2D.
Pathophysiology of diabetes: An overview - PubMed
2020年10月13日 · Diabetes mellitus is a chronic heterogeneous metabolic disorder with complex pathogenesis. It is characterized by elevated blood glucose levels or hyperglycemia, which results from abnormalities in either insulin secretion or insulin action or both.
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