2020年9月15日 · T-cell activation: initial interactions. CD8 + T cells interact with major histocompatibility complex class-1 (MHC-1) molecules 6 on the surface of antigen-presenting cells (APCs) and...

2023年11月1日 · Thymic mature CD8 T cells, known as naïve CD8 T cells, are poised to be activated after encountering specific antigens. Recent studies have highlighted the phenotypic and functional diversity...

The T cell receptor (TCR) on both CD4 + helper T cells and CD8 + cytotoxic T cells binds to the antigen as it is held in a structure called the MHC complex, on the surface of the APC. This triggers initial activation of the T cells.

Naïve CD8 T cells become activated when they recognize peptide antigen bound to MHC I at the surface of bone marrow–derived pAPCs. In contrast to other cells, pAPCs produce cytokines and express costimulatory molecules that are important for optimal CD8 T cell activation.

During an infection, naive CD8 + T cells are primed by antigen-presenting cells (APCs) in secondary lymphoid organs such as lymph nodes (LN) and spleen. How are the CD8 + T cells activated by the APCs? Seeing is believing.

2023年1月10日 · By studying human tumor-draining lymph nodes (TDLNs), we found that activated CD8 + T cells in TDLNs shared functional, transcriptional, and epigenetic traits with TCF1 + stem-like cells in the tumor.

Naïve CD8 T cells have the potential to differentiate into both short-lived effectors and memory precursors following activation. Short-lived effector cells are commonly defined as CD127 lo, KLRG-1 hi and express a panel of transcription factors, which promote effector activities but limit their proliferative capacity and survival. By contrast, memory precursors are typically CD127 …

CD8 + T cells are end effectors of cancer immunity. Most forms of effective cancer immunotherapy involve CD8 + T cell effector function. Here, we review the current understanding of T cell function in cancer, focusing on key CD8 + T cell subtypes and states.

2020年10月5日 · T cells follow a triphasic distinct pathway of activation, proliferation and differentiation before becoming functionally and phenotypically "exhausted" in settings of chronic infection, autoimmunity and in cancer.

2024年10月10日 · Central to their function are the CD4 and CD8 coreceptors, which mediate T cell activation and regulate immune responses. Understanding these coreceptors is vital for insights into how the immune system distinguishes between self and non-self, and how it mounts an effective defense against infections.