CD154, also called CD40 ligand or CD40L, is a protein that is primarily expressed on activated T cells [5] and is a member of the TNF superfamily of molecules. It binds to CD40 on antigen-presenting cells (APC), which leads to many effects depending on the target cell type.

Over time, many features and purposes of the CD40 signaling pathway were discovered, including the discovery of CD40 ligand (CD154/CD40L), a T cell surface molecule which is capable of induction of contact dependent differentiation of B cells.

CD40 binds its ligand CD40L, which is transiently expressed on T cells and other non-immune cells under inflammatory conditions. A wide spectrum of molecular and cellular processes is regulated by CD40 engagement including the initiation and progression of cellular and humoral adaptive immunity.

CD40 ligand (CD40L) is a 261-amino-acid membrane glycoprotein expressed on activated CD4 lymphocytes. Expression occurs shortly after T cell activation. The natural ligand for CD40L is CD40, which is a transmembrane protein present on …

CD40 and CD40 ligand (CD40L) have been well-documented as stimulatory immune checkpoint and play a broad role in various immunological processes contributing to both humoral and cell-mediated immune responses.

This article reviews recent developments in this field of research, with main emphasis on (1) structure and expression of CD40 and its ligand; (2) CD40 signal transduction; (3) in vitro function of CD40 on different cell types; and (4) in vivo functions of CD40/CD40-L interactions.

CD40 ligand (CD40L, also known as TNFSF5 or CD154) is a gene residing on the X chromosome that encodes for a critical costimulatory molecule expressed on T cells, providing the “secondary signal” to B cells to activate IgG production when binding …

The CD40 ligand (CD40L) is a transmembrane molecule of crucial interest in cell signaling in innate and adaptive immunity. It is expressed by a variety of cells, but mainly by activated T-lymphocytes and platelets. CD40L may be cleaved into a soluble form (sCD40L) that has a cytokine-like activity. Both forms bind to several receptors ...

The CD40 receptor and its ligand CD40L is one of the most critical molecular pairs of the stimulatory immune checkpoints. Both CD40 and CD40L have a membrane form and a soluble form generated by proteolytic cleavage or alternative splicing.

CD40 binds its ligand CD40L, which is transiently expressed on T cells and other non-immune cells under inflammatory conditions. A wide spectrum of molecular and cellular processes is regulated by CD40 engagement including the initiation and progression of cellular and humoral adaptive immunity.