The C-terminus (also known as the carboxyl-terminus, carboxy-terminus, C-terminal tail, carboxy tail, C-terminal end, or COOH-terminus) is the end of an amino acid chain (protein or polypeptide), terminated by a free carboxyl group (-COOH).

2021年8月30日 · C-terminus. C-terminus is one of the terminal groups of two ends of the peptide chain. The end of the polypeptide with a free Carboxyl group (-COOH) is known as C-terminus. This terminal group is also known as the carboxyl-terminal or c-terminal or carboxy-terminus.

Alternative splicing and proteolysis increase the diversity of proteins and peptides in cells with unique C-termini. The C-termini of proteins contain minimotifs, short peptides with an encoded function generally characterized as binding, posttranslational modifications, and trafficking.

2025年1月29日 · In brief, peptide identification was based on b- and y-series ions allowing for up to 1 missed cleavage and up to 1 non-enzymatic peptide terminus, variable peptide C-terminal amidation (−0. ...

The C-terminus (also known as the carboxyl-terminus, carboxy-terminus, C-terminal end, or COOH-terminus) of a protein or polypeptide is the end of the amino acid chain terminated by a free carboxyl group (-COOH). The convention for writing peptide sequences is to put the C-terminal end on the right and write the sequence from N- to C-terminus.

2023年11月7日 · Herein, a chemical approach to modify the C-terminus is developed by fusing a cysteine protease domain on the C-terminus of the protein of interest, which could achieve the non-enzymatic...

Explore N-terminus and C-terminus in proteins with Creative Proteomics's comprehensive guide, covering principles, methods, and detailed analysis.

C-terminal sequencing provides insights into structural motifs and modifications that can impact a protein's stability, activity, and conformation. This information aids in designing more effective therapeutic proteins and drugs.

Proteins, comprised of elongated sequences of amino acids, feature distinct terminal ends known as the N-terminus and C-terminus. These terminal points not only mark the inception and conclusion of a protein but also play pivotal roles in its synthesis, configuration, and biological function. What is the N-terminus and C-terminus? N-terminus.

The C terminus (residues 96–140) contains 15 acidic amino acids (10 Glu and 5 Asp residues) and the only 5 Pro residues of the protein (P108, P117, P120, P128, and P138). By means of its low hydrophobicity and high net charge, the C terminus is responsible for the intrinsically disordered nature of α-SYN.