A simple, efficient, and environmentally benign methodology allows the synthesis of β-amino alcohols from aromatic amines and alkylene carbonates in the presence of the highly active and reusable solid base catalyst Na-Y zeolite.

Beta-amino alcohol derivatives have attracted significant attention in medicinal chemistry due to their broad therapeutic applications. This review provides a comprehensive analysis of the synthesis methodologies and therapeutic potential of β-amino alcohol derivatives, highlighting their role in treating various diseases such as malaria ...

2020年6月22日 · Specifically, the enantio- and regioselective C–H amination of alcohols to access medicinally valuable chiral β-amino alcohols remains elusive. To solve this challenge, a radical relay chaperone...

2021年10月5日 · This review provides a comprehensive analysis of the synthesis methodologies and therapeutic potential of β-amino alcohol derivatives, highlighting their role in treating various diseases such as malaria, bacterial infections, cancer, tuberculosis, and Alzheimer's disease.

To explore an efficient and novel synthesis protocol for β-amino alcohols, we first reported a continuous-flow method for the preparation of β-amino alcohol derivatives catalyzed by lipase from Thermomyces lanuginosus in continuous-flow reactors (Scheme 1).

2020年10月30日 · A novel method for the synthesis of β-amino alcohols has been demonstrated under mild reaction conditions with a broad scope via a two-step Smiles rearrangement. What is more, theoretical calculations have been performed to confirm the rationality of the mechanism.

1994年8月1日 · New β-amino alcohols derived from L-valine as chiral inductors for enantioselective reductions of, and nucleophilic additions to carbonyl compounds. Tetrahedron 1995, 51 (1) , 165-172. https://doi.org/10.1016/0040-4020(94)00947-S

2002年9月18日 · The presence of a neighboring hydroxyl or amino group, respectively, is thought to activate β-amino alcohols toward these transformations. These protocols significantly increase access to a variety of arylated β-amino alcohols.

U.S. Pat. No. 6,800,764 titled ‘Process for synthesis of chirally pure beta-amino-alcohols’ discloses a process for preparing chirally pure S-enantiomers of alpha-amino acids from alkyl...

2016年7月7日 · Here we report a strategy for the direct aminolysis of nitroarenes with 1,2-epoxides through a tandem reduction and ring-opening process to prepare β-amino alcohols, which uses iron/NH 4 Cl in a mixture of water and ethanol.