2024年12月25日 · ZBP1 (Z-DNA Binding Protein 1) is a Protein Coding gene. Diseases associated with ZBP1 include Herpes Simplex and Influenza. Among its related pathways are …

ZBP1 recognizes DNA in the cytoplasm as an antiviral mechanism. Viral life cycles often include steps where DNA is exposed in the cytoplasm. DNA is normally contained in the nucleus of a …

2024年4月1日 · ZBP1 (also known as DNA-dependent activator of IFN regulatory factors [DAI] and DLM-1), a key sensor for Z -form nucleic acids (Z-NA), has been shown to function in …

2024年4月1日 · ZBP1, a cytosolic nucleic acid sensor, coordinates innate immune responses by initiating NF-κB and IRFs signaling pathways. It also causes inflammatory cell death …

ZBP1 activated innate immunity, including type-I interferon (IFN-I) response and NF-κB signaling, constitutes an important line of defense against pathogenic infection. In addition, ZBP1 …

Full length ZBP1 and a prominent splice variant lacking the first Zα domain (ΔZα) showed strikingly different subcellular localizations. While the full length protein showed a finely …

2024年6月1日 · ZBP1 lacking Zα1 domain localizes in large cytoplasmic granules which dynamically interact with SGs and PBs, while deletion of Zα2 domain or mutation of its …

2005年7月19日 · ZBP1 acts as an essential mediator of pyroptosis, necroptosis and apoptosis (PANoptosis), an integral part of host defense against pathogens, by activating RIPK3, …

Z-nucleic acid binding protein 1 (ZBP1) is an innate immune sensor recognizing nucleic acids in Z-conformation. Upon Z-nucleic acid sensing, ZBP1 triggers innate immune activation, …

2024年10月7日 · ZBP1, also known as Z-DNA binding protein 1, has emerged as a pivotal component in our understanding of the body’s immune response and its interaction with viral …