Biopolymers are extensively used for developing drug delivery systems as they are easily available, economical, readily modified, nontoxic, biodegradable and biocompatible. Thiolation is a well reported approach for enhancing mucoadhesive and mechanical properties of polymers.

2020年8月11日 · Thiolation is a well reported approach for enhancing mucoadhesive and mechanical properties of polymers. In the present review article, for the modification of biopolymers different thiolation methods and evaluation/characterization techniques have been discussed in detail.

In this review, we will focus on the thiolation strategies of the major biocompatible polysaccharides CTS and HA as promising platforms for the development of nanoparticulated DDS in anticancer therapy. In particular, we will discuss the main approaches published regarding the delivery of selected anticancer APIs such as taxanes and siRNAs. 2.

2020年8月1日 · Thiolation is an easily reproducible and efficient method for customization of mucoadhesive and mechanical properties of biopolymers for drug delivery applications. Biopolymers are extensively used for developing drug delivery systems as they are easily available, economical, readily modified, nontoxic, biodegradable and biocompatible.

2021年2月10日 · In order to obtain elastin with a high degree of thiolation recombinant elastin-like polypeptides with multiple periodic cysteine residues (cELP) were designed. These polypeptides were shown to form thermally responsive hydrogels that display rapid gelation under physiologically relevant, mild oxidative conditions via intermolecular disulphide ...

2020年8月11日 · Thiolation is a well reported approach for enhancing mucoadhesive and mechanical properties of polymers. In the present review article, for the modification of biopolymers...

2023年8月1日 · Thiolated polymers, or thiomers, are a class of polymers that exhibit unique mucoadhesive properties, allowing them to form strong covalent bonds with cysteine-rich subdomains of mucus glycoproteins. This property makes them ideal for developing drug delivery systems (DDSs) for various dry mucosal surface diseases.

Thiolation is a well reported approach for enhancing mucoadhesive and mechanical properties of polymers. In the present review article, for the modification of biopolymers di erent thiolation methods and evaluation/characterization techniques have been discussed in detail.

2020年6月22日 · Derived from chitin via deacetylation, chitosan displays a cationic charge, differentiating it from other polymers and making it a unique polysaccharide with properties like biocompatibility, biodegradability, and antimicrobial activity.

2020年8月11日 · Biopolymers are extensively used for developing drug delivery systems as they are easily available, economical, readily modified, nontoxic, biodegradable and biocompatible. Thiolation is a well reported approach for enhancing mucoadhesive and …