2024年12月25日 · TGFB3 (Transforming Growth Factor Beta 3) is a Protein Coding gene. Diseases associated with TGFB3 include Loeys-Dietz Syndrome 5 and Arrhythmogenic Right Ventricular Dysplasia, Familial, 1. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and MIF Mediated Glucocorticoid Regulation.

Transforming growth factor beta-3 is a protein that in humans is encoded by the TGFB3 gene. [5] [6] It is a type of protein, known as a cytokine, which is involved in cell differentiation, embryogenesis and development.

TGF-β3 is a more potent inhibitor of DNA synthesis in human keratinocytes compared to TGF-β1 and TGF-β2. TGF-β3 mRNA is expressed in lymphocytes such as CD4 + T cells, CD8 + T cells, γδT cells, and B cells. TGF-β3 has the potential to regulate systemic autoimmune diseases by inhibiting B cells.

2017年1月3日 · 研究发现骨质疏松症患者血清中TGF-β3浓度上升，其水平可能反映出骨组织中TGF-β3活性下降，从而促使骨质疏松的病理过程。 由于TGF-β1、TGF-β2和TGF-β3功能上的差异，不同的研究中要注意选择。 TGF-β 1和TGF-β 2诱导瘢痕的形成，而TGF-β 3却抑制瘢痕的形成。 在兔的伤口愈合过程中，bFGF会抑制TGF-β 1的表达，从而减轻瘢痕的形成。 一般来说肌腱组织很难在体外培养，而在不添加胎牛血清，添加10 ng/ml的TGF-β3和50 ng/ml的IGF-1的培养 …

2021年8月4日 · Here, we show that the latent forms of TGFβ2 and TGFβ3 can be activated by integrin-independent mechanisms and have lower activation thresholds compared to TGFβ1. Unlike TGFB1, TGFB2 and TGFB3 expression is increased in human lung and liver fibrotic tissues compared to healthy control tissues.

TGF-b3 is a direct target of miR-29c. Elevated levels of TGF-b3 in fibroids induce the expression of DNMT1, which in turn increases the methylation of miR-29c promoter and its reduced expression. TGFb/Activin signaling is activated through an ActivinB autocrine mechanism in a subset of Group 3 medulloblastmas.

该基因编码 TGF-β (转化生长因子-β) 蛋白质超家族的分泌配体。 该家族的配体结合各种 TGF-β 受体，导致调节基因表达的 SMAD 家族转录因子的募集和激活。 编码的前原蛋白经过蛋白水解处理以生成潜伏相关肽 (LAP) 和成熟肽，并且以由成熟肽同二聚体、LAP 同二聚体和潜伏 TGF-β 结合蛋白组成的潜伏形式被发现，或者以仅由成熟肽同源二聚体组成的活性形式存在。 成熟肽还可以与其他 TGF-β 家族成员形成异二聚体。 这种蛋白质参与胚胎发生和细胞分化，并可能在伤口愈 …

The TGFB3 gene provides instructions for producing a protein called transforming growth factor beta-3 (TGFβ-3). This protein is found throughout the body and is required for development before birth and throughout life. To carry out its functions, TGFβ-3 attaches (binds) to receptor proteins on the surface of cells.

2025年1月4日 · Title: TGFB3 gene mutation associated with mandibular coronoid process hyperplasia: a family investigation. TGF-beta3 in differentiation and function of Tph-like cells and its relevance to disease activity in patients with systemic lupus erythematosus.

2024年11月27日 · Clinical resource with information about TGFB3, Arrhythmogenic right ventricular dysplasia 1, Rienhoff syndrome, and available tests. There are links to practice guidelines and authoritative resources like GeneReviews, PubMed, MedlinePlus, PharmGKB and clinicaltrials.gov.