Structural mechanism of ergosterol regulation by fungal sterol ...
2015年2月6日 · Transcriptional regulation of ergosterol biosynthesis in fungi is crucial for sterol homeostasis and for resistance to azole drugs. In Saccharomyces cerevisiae, the Upc2 …
Sterol-Response Pathways Mediate Alkaline Survival in Diverse Fungi …
2020年6月16日 · Here, we define potential interactions among fungal sterol homeostasis, alkaline pH tolerance, and Rim pathway activation. We find that the sterol homeostasis pathway is …
Ergosterol distribution controls surface structure formation and …
Mechanisms of sterol transport have been examined in model yeast but not in fungal pathogens, and the relationship between sterol organization and fungal pathogenesis remains unexplored. …
Mechanisms of sterol uptake and transport in yeast
2012年3月1日 · Basic pathways for the intracellular transport of sterols in yeast. Major cellular compartments are indicated, arrows indicate sterol transport pathways and proteins implicated …
Insights into the role of sterol metabolism in antifungal drug ...
2024年10月10日 · The majority of sterol transport in yeast occurs via non-vesicular transport pathways mediated by lipid transfer proteins, which determine the quantity of sterol present in …
Regulation of Ergosterol Biosynthesis in - PMC
The detailed study of the molecular mechanisms that contribute to the regulation, synthesis and transport of sterols in S. cerevisiae and fungal pathogens is crucial for the design of new …
The Multifunctional Fungal Ergosterol - PMC
Upc2, the transcription factor required for pyroptosis in the C. albicans model, is directly related to the ergosterol biosynthesis pathway. This transcriptional regulator senses the intracellular …
The SREBP (Sterol Regulatory Element-Binding Protein) pathway: …
2021年10月26日 · Recently, it has been demonstrated that carotenogenesis in X. dendrorhous is regulated by the SREBP (Sterol Regulatory Element-Binding) pathway [17], which is a …
Yeast metabolic engineering – Targeting sterol ... - ScienceDirect
2013年7月1日 · Sterol biosynthesis pathways starting from squalene with sterol intermediates and end products in fungi (blue), plants (green) and animals (red). Solid arrows indicate naturally …
Sterol biosynthesis and sterol uptake in the fungal pathogen
2010年10月1日 · The sterol biosynthetic pathway in fungi and mammals is strikingly similar, but differences in the later steps of both pathways result in two structurally different molecules. …