Endoplasmic reticulum (ER)-localized 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase (HMGCR), the rate limiting enzyme in the mevalonate pathway, is the focus of a …

Sterol synthesis is a complex and intertwined pathway, which includes at least two rate-limiting enzymes, HMGCR and SQLE. The role of sterol synthesis in cancer stems from several levels …

Sterol biosynthesis is induced by nuclear translocation of the transcription factor sterol regulatory element–binding protein (SREBP), which transactivates approximately 20 enzymes involved in …

Thus, in this section, we aimed to summarize key enzymes in the post-squalene pathway of the plant sterols biosynthesis, which is crucial for plant responses to abiotic stress, mainly through …

2014年7月3日 · Through the DiatomCyc database we reconstructed the mevalonate and sterol biosynthetic pathways of the model diatom Phaeodactylum tricornutum in silico. We …

2021年11月5日 · Typical strategies include regulating the ergosterol synthesis pathway via enhancing the pathway flux by restriction of the competing branches, strengthening precursor …

2021年8月1日 · Understanding the origin of sterol biosynthesis genes, why certain bacteria have these genes, and whether the sterols produced by bacteria perform similar functional roles …

In this review, we present the synthesis of ergosterol in the opportunistic pathogenic fungus C. albicans and summarize key genetic mutations in ergosterol biosynthesis and transcriptional …

Based on these and structure-function studies, we have introduced a new strategy to inhibit sterol biosynthesis in pathogenic organisms and parasites that are responsible for neglected …

2024年3月28日 · The primary sterol synthesis pathways discussed in this review, demonstrating potential chemical inhibitors for each of the key enzyme steps.