Sterol regulatory element-binding proteins (SREBPs) are transcription factors that bind to the sterol regulatory element DNA sequence TCACNCCAC. [2] Mammalian SREBPs are encoded by the genes SREBF1 and SREBF2. SREBPs belong to the basic-helix-loop-helix leucine zipper class of transcription factors. [3]

2019年3月22日 · Sterol regulatory element binding proteins (SREBPs) are a family of transcription factors that regulate lipid biosynthesis and adipogenesis by controlling the expression of several...

Sterol regulatory element-binding protein 1 (SREBP-1) is an important regulator of lipogenesis and a key player in converting carbohydrates into FA and triglyceride storage in cytoplasmic droplets. SREBP-1 is highly upregulated in cancers and was identified as a prerequisite for developing brain metastasis in breast cancer [ 136 , 137 ].

Roles of sterol regulatory element-binding proteins (SREBPs) have been established as lipid synthetic transcription factors especially for cholesterol and fatty acid synthesis. SREBPs have unique characteristics. Firstly, they are membrane-bound proteins and the N-terminal active portions enter nucl …

2017年8月29日 · Sterol regulatory-element binding proteins (SREBPs) are transcription factors that regulate the expression of genes involved in lipid synthesis and function as key nodes of convergence...

2019年3月22日 · Sterol regulatory element binding proteins (SREBPs) are a family of transcription factors that regulate lipid biosynthesis and adipogenesis by controlling the expression of several enzymes required for cholesterol, fatty acid, triacylglycerol and phospholipid synthesis.

2001年11月1日 · This nuclear SREBP, then enters the nucleus and activates the transcription of genes involved in cholesterol and fatty acid synthesis by binding to sterol regulatory elements (SREs) or to palindromic sequences called E-boxes within their promoter regions. SREBP precursor and SCAP form a complex on the rough endoplasmic reticulum (ER) membrane [9].

SREBPs are synthesized as precursor proteins in the endoplasmic reticulum (ER), where they form a complex with another protein, SREBP cleavage activating protein (SCAP). The SCAP molecule contains a sterol sensory domain. In the presence of high cellular sterol concentrations SCAP confines SREBP to the ER.

2 天之前 · Sterol regulatory element-binding protein 2 (SREBP2, about 120 kDa), which is cleaved into two fragments of around 60 kDa each at low cholesterol levels in the ER membrane, was used as a marker to ...

Sterol regulatory element binding proteins (SREBPs) are transcription factors that have central roles in lipid metabolism, controlling expression of lipid synthesis genes. There are two SREBP proteins: SREBP 1 and 2.