2023年7月10日 · Salicylate toxicity is a medical emergency. Intentional ingestion or accidental overdose can cause severe metabolic derangements making treatment difficult. Co-ingestion of other medications can further complicate management.

2021年10月1日 · Acid-base status can suggest salicylate toxicity, but cannot exclude it. Note also that patients with co-ingestion may not manifest with classic acid/base patterns (e.g., aspirin plus opioids may not lead to a respiratory alkalosis).

2020年11月3日 · Salicylates in acute overdose classically cause a respiratory alkalosis by stimulating the respiratory centres in the brain followed by a metabolic acidosis by uncoupling oxidative phosphorylation. The classic triad of mild toxicity is nausea, vomiting and tinnitus,

Salicylate poisoning, also known as aspirin poisoning, is the acute or chronic poisoning with a salicylate such as aspirin. [1] The classic symptoms are ringing in the ears, nausea, abdominal pain, and a fast breathing rate. [1] Early on, these may be subtle, while larger doses may result in …

Acute ingestion of > 150 mg/kg of salicylate can cause severe toxicity. Salicylate tablets may form bezoars, prolonging absorption and toxicity. Chronic toxicity can occur after several days or more of high therapeutic doses; it is common, often undiagnosed, and often more serious than acute toxicity. Chronic toxicity tends to occur in older ...

2020年6月24日 · This article highlights the risk factors for salicylate toxicity; reviews the pathophysiological effects; notes the hidden sources of salicylates, including foods, drugs, and topical ointments...

2024年5月28日 · A high index of suspicion of salicylate toxicity is necessary, with prompt recognition of clinical signs and symptoms of salicylate poisoning, such as tinnitus, hyperventilation,...

Salicylate toxicity is a complex problem that may develop with either acute or chronic exposure to salicylates. Salicylates are found in over-the-counter medications including aspirin, bismuth subsalicylate, effervescent antacids, ointments, liniments, and oil of wintergreen (methyl salicylate) and alternative medication products (e.g., willow ...

2024年3月22日 · Salicylate poisoning is potentially fatal. It can present acutely or indolently with more chronic exposure. Diagnosis should be considered in any patient presenting with a history of unknown toxin ingestion or exposure, particularly in the …

salicylate toxicity such as hematemesis, tachypnea, hyperpnea, dyspnea, tinnitus, deafness, lethargy, seizures, unexplained lethargy, or confusion warrants referral to an emergency department for evaluation (Grade C).