2002年12月1日 · Since their initial discovery, ribozymes have shown great promise not just as a tool in the manipulation of gene expression, but also as a novel therapeutic agent. This review …

Since their initial discovery, ribozymes have shown great promise not just as a tool in the manipulation of gene expression, but also as a novel therapeutic agent. This review discusses …

1998年1月15日 · Ribozymes are catalytic RNA molecules that recognize their target RNA in a highly sequence-specific manner. They can therefore be used to inhibit deleterious gene …

2019年12月23日 · In this study, we engineered a class of type III hammerhead ribozymes to develop RNA switches that are highly efficient at cis -cleaving mammalian mRNAs and …

Because of their ability to interact directly with mRNA, ribozymes are currently being developed by a small number of com panies as potential therapeutic agents in a wide range of diseases,...

2001年5月1日 · Current gene therapy applications employ variations on naturally occurring ribozymes, but in vitro selection has provided new RNA and DNA catalysts, and research on …

2010年10月1日 · Ribozymes and riboswitches are RNA-based therapeutic tools that are most often employed to knockdown gene expression and to inhibit bacterial infections, respectively. …

Since the breakthrough discovery of catalytic RNAs (ribozymes) in the early 1980s, valuable ribozyme-based gene therapies have been developed for incurable diseases ranging from …

2024年11月14日 · Ribozyme cleavage generates distinct 2′,3′-phosphate and 5′-hydroxyl termini that resemble substrates for recently characterized RNA repair pathways in cells. We report …

2023年8月28日 · By harnessing this catalytic power, researchers have explored the development of ribozyme-based therapies, also known as ribozyme therapeutics. The primary premise is to …