The immunogenetics of RA suggest a key role for aberrant pathways of T-cell activation in the initiation and/or perpetuation of disease. In the T-cell activation process, CD4+ T-cells are …

Innate immune cells, including mast cells, dendritic cells (DCs), innate lymphocytes and adaptive immune cells, such as B cells, plasma cells, follicular regulatory T (TFR) cells and helper T …

2022年1月24日 · During the onset and progression of autoimmune diseases (such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA)), T cells become resistant to …

Thus, both naïve and memory T cells may proliferate and differentiate in response to the inflammatory milieu into effector T-cell populations with specific cell surface phenotypes and …

In this Review, Cornelia Weyand and Jörg Goronzy introduce the key role that T cells have in the pathogenesis of rheumatoid arthritis and discuss the development and application of T-cell...

2008年10月15日 · In this study, Gene Ontology pathway analysis suggested that many pathways active in T cells, including JAK/STAT (Janus kinase/signal transducer and activator of …

2024年5月1日 · Regulatory T cells (Tregs), which play a crucial role in controlling ongoing autoimmunity and maintaining peripheral tolerance, have shown great potential for the …

2021年4月1日 · The loss or functional deficiency of key immune cells, regulatory T (Treg) cells, has been confirmed in human autoimmune diseases. The pathogenesis of RA is complex, and …

2022年10月10日 · Evidence demonstrated that metabolic-associated T cell abnormalities could be detected in the early stage of RA development. In this context, molecular evaluations have …

In rheumatoid arthritis (RA), T cells infiltrate into the synovial membrane where they initiate and maintain activation of macrophages and synovial fibroblasts, transforming them into tissue …