Here we dissect the etiology and pathology at specific stages: (i) triggering, (ii) maturation, (iii) targeting, and (iv) fulminant stage, concomitant with hyperplastic synovium, cartilage damage, bone erosion, and systemic consequences.

2019年11月9日 · Summarize the pathophysiology of rheumatoid arthritis. Outline the use of rheumatoid factor and anti-citrullinated protein antibodies in evaluating rheumatoid arthritis. Review the importance of improving care coordination among the interprofessional team to improve outcomes for those affected with rheumatoid arthritis.

Rheumatoid arthritis is best characterized as an immune mediated inflammatory disease (IMID). Within a framework that recognizes both immunological activation and inflammatory pathways, we can begin to evaluate the multiple components of disease initiation and propagation.

2018年4月27日 · Here we dissect the etiology and pathology at specific stages: (i) triggering, (ii) maturation, (iii) targeting, and (iv) fulminant stage, concomitant with hyperplastic synovium, cartilage...

2023年6月30日 · Our deeper understanding of the pathogenesis of RA has led to greater insights into how available therapies work and the development of new approaches to more effectively control disease activity and prevent joint injury. The pathogenesis of RA is reviewed here.

2023年6月1日 · This review summarizes pathophysiology of RA, recent conventional therapeutic agents and advancement in the current therapies of RA with more emphasis on targeted novel drug delivery systems (NDDS), safety and toxicological aspects of therapy, related patents, clinical trials progression with application of NDDS for RA therapy.

Rheumatoid arthritis (RA) is a chronic inflammatory and autoimmune disease with multisystem involvement, including genetic, epigenetic, metabolic, and immune factors. This review focuses on the importance of recently identified epigenetic and metabolic risk factors for immune dysfunction and pathogenic tissue‐remodeling programs in RA ...

2018年2月8日 · In this Primer, we discuss the epidemiology, pathophysiology, diagnosis and management of RA. Rheumatoid arthritis is a chronic, inflammatory, autoimmune disease that primarily affects the...

Rheumatoid arthritis (RA) is a chronic, systemic autoimmune disease associated with synovial tissue proliferation, pannus formation, cartilage destruction, and systemic complications.

2011年12月8日 · Rheumatoid arthritis is characterized by synovial inflammation and hyperplasia (“swelling”), autoantibody production (rheumatoid factor and anti–citrullinated protein antibody [ACPA]),...