Drug response, either drug efficacy or adverse drug reactions, is usually controlled by a network of genes that operate independently or interactively [6]. Moreover, the effects triggered by the genes rely on the genetic background of a patient and his/her lifestyle as well as the change in the body’s metabolic environment arising from drug ...

The way a person responds to a drug is affected by many factors, including. Genetic makeup. Age. Body size. Use of other drugs and dietary supplements (such as medicinal herbs) Consumption of food (including beverages) Presence of diseases (such as kidney or liver disease) Storage of the drug (whether the drug was stored too long or in the ...

Drug response is the consequence of interactions among drug, disease, and body (Fig. 3). The interactions between drug and body can be quantified by pharmacokinetics (focusing on how the body processes a drug, resulting in a drug concentration) and pharmacodynamics (concerned with how the drug acts on the body, resulting in a measurable drug ...

2016年6月9日 · This chapter will introduce the concept of dose-response curves and some of the terms (e.g., potency, selectivity, maximum effect) used to describe responses to drugs. Comparison of the two major types of responses, graded and quantal, will emphasize the important principle that the dose-response relationship underlies medication decisions.

The plasticity of responses to drugs is an ever-present confounding factor for all aspects of pharmacology, influencing drug discovery and development, clinical use and the expectations of the patient.

The goal of this review is to describe the contribution of genetic variation to drug response, with a focus on drugs used in cardiovascular therapy. Genetic approaches used to analyze rare and common adverse effects as well as variability in efficacy are first presented.

Drug response or adverse effect is the net effect of multiple factors: age, organ function, concomitant therapy, drug interactions, and disease. In addition to these, there are now numerous examples of cases where interindividual differences in drug response are due to sequence variants in genes encoding drug-metabolizing enzymes, drug ...

In humans, positive effects of drugs facilitate continued use of a drug while negative effects discourage use, and in nonhumans, greater genetic risk for drug intake is predicted by reduced sensitivity to drug aversive effects; but whether these initial responses affect escalation of drug use, and the development of dependence is currently unknown.

2011年3月24日 · The tumor genome plays a critical role in the response to gefitinib (Panel A), since the sensitivity of non–small-cell lung cancer to this drug is enhanced by activating mutations in the kinase...

2022年12月9日 · In this study, we propose a method called LGRDRP (Learning Graph Representation for Drug Response Prediction) to predict cell line-drug responses. At first, LGRDRP constructs a heterogeneous network integrating multiple kinds of information: cell line miRNA expression profiles, drug chemical structure similarity, gene-gene interaction, cell ...