Prolyl isomerase (also known as peptidylprolyl isomerase or PPIase) is an enzyme (EC 5.2.1.8) found in both prokaryotes and eukaryotes that interconverts the cis and trans isomers of …

Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1) is an evolutionally conserved and unique enzyme that specifically catalyzes the cis-trans isomerization of phosphorylated …

2018年8月29日 · Pin1 is the only known peptidyl-prolyl cis – trans isomerase (PPIase) that specifically recognizes and isomerizes the phosphorylated Serine/Threonine-Proline (pSer/Thr …

2020年3月31日 · In this review, we summarize the findings on the dysregulation, mechanisms, and biological functions of Pin1 in cancer cells, and also discuss the significance and potential …

The recent identification and characterization of a peptidyl-prolyl cis/trans isomerase (PPIase), Pin1, which specifically regulates the conformation of specific Pro-directed phosphorylation …

PIN1-catalysed phosphorylation-dependent prolyl isomerization has emerged as a unique molecular timer that modulates its multiple targets at various steps of a given cellular process to...

Since its discovery 10 years ago, Pin1, a prolyl cis/trans isomerase essential for cell cycle progression, has been implicated in a large number of molecular processes related to human …

2015年5月18日 · The prolyl isomerase Pin1 regulates mRNA levels of genes with short half-lives by targeting specific RNA binding proteins. PLoS ONE. 2014; 9 :e85427. doi: …

2002年10月2日 · Our results suggest that, following stress-induced phosphorylation, p53 needs to form a complex with Pin1 and to undergo a conformational change to fulfil its biological roles. …

Prolyl isomerase Pin1 promotes amyloid precursor protein (APP) turnover by inhibiting glycogen synthase kinase-3beta (GSK3beta) activity: novel mechanism for Pin1 to protect against …