2005年6月20日 · Otto Isler (left) did pioneering work for Roche in the 1940s on the synthesis of vitamins A, E, and K. He is shown in his lab with his assistant Gody Ryser.

2016年3月31日 · In the same year, Isler et al. established a modification to the Arens-van Dorp synthesis which was better suited for industrial scale-up at Hoffmann-La Roche. The synthesis of vitamin A assisted in the advancement of synthetic chemistry, through the work and development of reactions by well-known chemists such as Wittig, Lindlar and Julia.

Isler synthesis and modification (Hoffmann-La Roche) Otto Isler also began research into vitamin A around the same time as Arens and van Dorp, with his first major paper on the

1979年1月1日 · Price of vitamin A and Roche's capacity 456 OTTO ISLER an impressive cheapening of the average price which in 1976 was less than 3% of that in 1948. Roche is manufacturing vitamin A in Switzerland and USA as well as in India.

Editors: Otto Isler, Hugo Gutmann, Ulrich Solms. Series Title: Lehrbücher und Monographien aus dem Gebiete der exakten Wissenschaften. DOI: https://doi.org/10.1007/978-3-0348-5831-1. …

Otto Isler Am Landungssteg, CH-8592 Uttwil, Switzerland Abstract A review is given of the development industrial manu­ facture of carotenoids and vitamin A by isolation synthesis. Special emphasis is placed on the use of carotenoids as a preferred class of colouring matters for food and feed • . INTRODUCTION

Isler, Otto，现任职于F. Hoffmann-La Roche AG，曾任职于利物浦大学、匹兹堡大学等机构，个人H指数为24，累计发表论文80篇，论文总被引数累计1703次，主要研究方向涵盖生物化学,遗传学和分子生物学、化学、化学工程、医学等领域，在Nature、Justus Liebigs Annalen der Chemie ...

2020年10月30日 · The Swiss company Hoffmann-La Roche then developed, under the leadership of Otto Isler, an industrially viable route to vitamin A. Several plants were brought into operation at the end of the 1950s. In parallel, BASF developed another vitamin A synthesis together with Georg Wittig, the decisive step of which was a Wittig reaction between a C 15 ...

Otto Isler (* 4. August 1910 in Schaffhausen; † 28. September 1992 in Uttwil) war ein Schweizer Chemiker. Er war Bürger von Wagenhausen und ab 1951 von Basel. Otto Isler war der Sohn eines Realschullehrers und studierte Chemie an der ETH Zürich, an der er 1935 bei Leopold Ruzicka mit einer Dissertation über Betulin promoviert wurde.

1992年9月28日 · Synthesen des Betacarotins (Provitamin A) und weiterer Carotinoide. 1954 Leiter der chem. Forschungsabteilung, 1973-75 in der Konzernleitung von La Roche. Ehrendoktorate der Univ. Amsterdam 1971 und Basel 1980 sowie Paul-Karrer-Medaille 1975.