Complex I is the first enzyme of the respiratory chain. It oxidizes NADH, which is generated through the Krebs cycle in the mitochondrial matrix, and uses the two electrons to reduce …

2016年7月1日 · Complex I comprises 14 central subunits that execute the core bioenergetic functions and that are conserved from bacteria to humans. The central subunits can be divided …

2016年8月10日 · Complex I (NADH:ubiquinone oxidoreductase), one of the largest membrane-bound enzymes in the cell, powers ATP synthesis in mammalian mitochondria by using the …

2021年11月12日 · Mitochondrial NADH:ubiquinone oxidoreductase (complex I) is the largest and most intricate membrane protein complex of the respiratory chain (1–4). Complex I couples the …

2020年8月1日 · Respiratory complex I (NADH:ubiquinone oxidoreductase) is a redox-driven proton pump. Bacterial MBH and plastid NDH are members of the complex I superfamily. …

2006年9月1日 · This review examines two aspects of the structure and function of mitochondrial Complex I (NADH Coenzyme Q oxidoreductase) that have become matter of recent debate. …

2020年8月3日 · Here, we describe a 2.7-Å-resolution structure of the 42-subunit complex I from the yeast Yarrowia lipolytica containing 275 structured water molecules. We identify a proton …

2016年9月5日 · Here we present a nearly complete atomic structure of ovine (Ovis aries) mitochondrial complex I at 3.9 Å resolution, solved by cryo-electron microscopy with cross …

We here review recent progress in structure determination, and in understanding the role of accessory subunits and functional analysis of mitochondrial complex I. For the central …

2018年7月25日 · Complex I has an essential role in ATP production by coupling electron transfer from NADH to quinone with translocation of protons across the inner mitochondrial membrane. …