2024年11月26日 · Lipid peroxidation inhibition (e.g., exogenous supplement with vitamin E or increasing GPX4 expression) represents a promising therapeutic option for several diseases …

2017年7月27日 · We identify vulnerability to ferroptic cell death induced by inhibition of a lipid peroxidase pathway as a feature of therapy-resistant cancer cells across diverse …

Here we molecularly characterize this therapy-resistant high-mesenchymal cell state in human cancer cell lines and organoids and show that it depends on a druggable lipid-peroxidase …

2017年7月5日 · Here we molecularly characterize this therapy-resistant high-mesenchymal cell state in human cancer cell lines and organoids and show that it depends on a druggable lipid …

2017年7月1日 · 在这里，我们在分子上表征了人类癌细胞系和类器官中这种抗治疗的高间充质细胞状态，并表明它依赖于一种可药物的脂质过氧化物酶途径，该途径可以防止铁死亡，这是一种 …

2024年9月1日 · There are three necessary stages involving in the process of lipid peroxidation regulation in ferroptosis, including the synthesis of membrane phospholipids, initiation of lipid …

2023年5月2日 · Lipid peroxidation of phospholipid bilayers can promote mitochondrial apoptosis, endoplasmic reticulum stress, and other complex molecular signaling pathways to regulate …

6 天之前 · Glutathione peroxidase 4 (GPX4), ... Seashore-Ludlow B, et al. Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway. Nature. 2017;547:453–7.

2023年4月10日 · GPX4 inhibition kills cancer cells in the mesenchymal state that display a therapy-resistant and metastatic phenotype and depend on the lipid peroxidase pathway [16, …

Lipid peroxidation, or lipid oxidation, is a complex chemical process that leads to oxidative degradation of lipids, [1] resulting in the formation of peroxide and hydroperoxide derivatives. …