In this study, we examined the integrity of thalamostriatal synaptic transmission in striatonigral and striatopallidal MSNs of Sapap3 KO mice. Surprisingly, our results show that Sapap3 deletion …

2014年4月15日 · In mice, genetic deletion of Sapap3 causes obsessive-compulsive disorder (OCD)-like behaviors that are rescued by striatal expression of Sapap3, demonstrating the …

his study, we investigate excitatory synaptic transmission of striatal medium spiny neurons ( SNs) in acute brain slices from Sapap3 KO mice. We find that loss of SAPAP3 results in abnormal …

2017年9月5日 · Here, we use patch-clamp electrophysiology, and two-photon calcium imaging and glutamate uncaging, to show that supralinear dendritic integration of near-synchronous …

2009年4月22日 · Single and dual voltage-clamp recordings were performed using the whole-cell configuration of the patch-clamp technique at a pipette voltage of −60 mV using the Axopatch …

2017年9月5日 · Here we find that a single class of interneuron, fast-spiking interneurons (FSIs), modulates all of these habit-predictive properties. Consistent with a role in habits, FSIs are …

2016年10月1日 · Whole-cell patch-clamp recordings obtained at 23°C–25°C were used to measure excitatory postsynaptic currents using methods described in the Supplement. …

Kristen ADE, Vice President and Chief Scientific Officer | Cited by 897 | | Read 17 publications | Contact Kristen ADE

marker proteins were used to distinguish SN and SP MSNs (20). Whole-cell patch-clamp recordings were made as described in (6). Cortical afferents were evaluated using coronal …

2016年2月3日 · By imaging cortically evoked firing in large populations of pathway-defined striatal projection neurons (SPNs), we identify features that strongly correlate with habitual behavior …