2023年10月10日 · Use of compounded ketamine products without monitoring by a health care provider for sedation (sleepiness), dissociation (disconnection between a person’s thoughts, feelings, and sense of...

Ketamine is a chiral compound. The more active enantiomer, esketamine (S-ketamine), is also available for medical use under the brand name Ketanest S, [136] while the less active enantiomer, arketamine (R-ketamine), has never been marketed as an enantiopure drug for clinical use. While S-ketamine is more effective as an analgesic and anesthetic ...

Ketamine is an NMDA receptor antagonist with a potent anesthetic effect. It was developed in 1963 as a replacement for phencyclidine (PCP) by Calvin Stevens at Parke Davis Laboratories.

2022年2月16日 · Ketamine is a racemic mixture consisting of two mirror image molecules, R- and S-ketamine. FDA-approved labeling for ketamine contains warnings and precautions on hemodynamic instability,...

2024年4月9日 · Ketamine is a chemical compound used as an anesthetic in humans and animals. 1,2 It was developed decades ago as a less toxic alternative to the drug phencyclidine (PCP), which was also developed as an anesthetic.

We found ketamine to be a well-tolerated and effective treatment for the triad of severe anxiety, chronic pain, and severe depression in a hospice patient with multiple comorbid conditions. To our knowledge, this report chronicles the first use of compounded oral ketamine for home-based palliative or hospice care in Louisiana.

Ketamine Hydrochloride is the hydrochloride salt of a synthetic derivative of cyclohexanone with analgesic and anesthetic activities.

On October 10, 2023, the U.S. Food and Drug Administration (FDA) issued a public warning regarding the potential health risks associated with compounded ketamine products.

2021年3月9日 · Ketamine hydrochloride (C 13 H 16 ClNO.HCl, MW 274.2) occurs as a white, crystalline powder with a slight, characteristic odor. Approximately 1.15 mg is equivalent to 1 mg of ketamine base. Ketamine hydrochloride is soluble 1 g in 4 mL of water, in 14 mL of alcohol, and in 60 mL of absolute alcohol.

For more than 50 years, ketamine has proven to be a safe anesthetic drug with potent analgesic properties. The active enantiomer is S (+)‐ketamine. Ketamine is mostly metabolized in norketamine, an active metabolite.