Histone acetylation and deacetylation are the processes by which the lysine residues within the N-terminal tail protruding from the histone core of the nucleosome are acetylated and deacetylated as part of gene regulation.

Histone H3 acetylation plays a pivotal role in gene expression regulation, DNA damage repair and modulation of cellular signaling or protein–protein interactions, affecting cell division and proliferation in various cancer types, including breast, lung, colorectal, bladder and prostate cancers, as a consequence.

2024年10月12日 · Here, we discuss recent findings on the acetylation of the highly conserved histone protein H3 in the context of cancer biology. Specifically, we review the acetylation of particular H3 residues in various cancer types. We further highlight the significance of H3 acetylation levels as a potential cancer biomarker with prognostic implications.

2016年4月18日 · Here we show that acetylation of lysine residues in the globular domain of histone H3 (lysine 64 (H3K64ac) and lysine 122 (H3K122ac)) marks active gene promoters and also a subset of active...

2024年10月12日 · Histone H3 acetylation plays a pivotal role in gene expression regulation, DNA damage repair and modulation of cellular signaling or protein–protein interactions, affecting cell division and proliferation in various cancer types, including breast, lung, colorectal, bladder and prostate cancers, as a consequence.

2024年1月10日 · Acetylation of histones is highly consequential to gene transcription. HATs and HDACs play critical roles in adding and erasing lysine acetylation. Recent cryoEM structures of HAT and HDAC complexes suggest many interesting parallels in how they assemble and function.

2014年3月25日 · In this study, we investigate acetylation of histone H3 at lysine 64 (H3K64ac), a previously uncharacterized acetylation on the lateral surface of the histone octamer. We show that H3K64ac regulates nucleosome stability and facilitates nucleosome eviction and hence gene expression in vivo.

2017年9月1日 · Here, we describe a functional role for H3K9ac in promoting pol II pause release by directly recruiting the super elongation complex (SEC) to chromatin. H3K9ac serves as a substrate for direct binding of the SEC, as does acetylation of histone H4 lysine 5 …

2025年1月13日 · Histone H3 modifications play a pivotal role in determining cell fate during development in response to environmental cues. Methylation of lysine 9 on histone H3 (H3K9me) is an epigenetic modification that represses gene expression by facilitating the formation of heterochromatin [1,2,3,4].Conversely, acetylation at the same lysine residue (H3K9ac) enhances nucleosome accessibility to the ...

While H3 K9 methylation defines condensed heterochromatin that is able to silence a nearby gene, how gene silencing within euchromatin regions is achieved remains elusive. We report here that histone H3 K4 methylation or K9/K14 acetylation defines distinct chromatin regions permissive or nonpermissive for transgene expression.