Free Cholesterol Determines rHDL Phospholipid Phase Structure …
2013年6月6日 · Reassembled high density lipoproteins (rHDL) of various sizes and compositions containing apo A-I or apo A-II as their sole protein, dimyristoyl phosphatidylcholine (DMPC), …
Cholesterol and Cholesterol Esters - structure, occurrence ...
Cholesterol esters, i.e., with long-chain fatty acids linked to the hydroxyl group, are much less polar than free cholesterol, and they appear to be the preferred form for transport in plasma …
21.5: Biosynthesis of Cholesterol and Steroids
Cholesterol has vital structural roles in membranes and in lipid metabolism in general with an extraordinary diversity of biological roles, including cell signaling, morphogenesis, lipid …
Mechanisms and regulation of cholesterol homeostasis
2019年12月17日 · In this Review, we discuss the latest advances regarding how each of the four parts of cholesterol metabolism is executed and regulated. The key factors governing these …
Homeostasis of free cholesterol in the blood: a preliminary …
The rate of noncatalyzed transfer of cholesterol (Chol) among lipoproteins and cells in the blood is of fundamental importance as a baseline to assess the role of active transport mechanisms, …
Free cholesterol determines reassembled high-density lipoprotein ...
2013年6月25日 · Direct Measurement of the Structure of Reconstituted High-Density Lipoproteins by Cryo-EM. Variations in cholesterol distribution between nanoscale HDL discs are due to …
Lipoprotein Structure and Dynamics: Low Density ... - IntechOpen
2012年10月3日 · LDLs are built up by a hydrophobic lipid core of cholesterylester (CE) and triglyceride (TG) molecules, which make up more than 40% of particle mass surrounded by a …
The molecular structure of LDL has finally been elucidated
2025年1月28日 · a, The structure of apolipoprotein B100 (apoB100) by Ren et al., showing the β-sheet-rich domains and the amphipathic α-helix-rich domains projected onto an LDL particle 3. …
Regulation of cholesterol homeostasis in health and diseases: …
2022年8月2日 · Daily food and the hepatic endogenous synthesis are the two main sources of human cholesterol, of which dietary free cholesterol (FC) uptake is mediated by Niemann-Pick …
Molecular Pathways Underlying Cholesterol Homeostasis - PMC
Free cholesterol (FC) transported in the micelles enter the enterocyte through NPC1L1 and is esterified by ACAT2 in the endoplasmic reticulum (ER). Free cholesterol returns to the …